Deciphering the role of phage in the cystic fibrosis airway

Willner, Dana and Furlan, Mike (2010) Deciphering the role of phage in the cystic fibrosis airway. Virulence, 1 4: 309-313.

Author Willner, Dana
Furlan, Mike
Title Deciphering the role of phage in the cystic fibrosis airway
Journal name Virulence   Check publisher's open access policy
ISSN 2150-5594
Publication date 2010-07-01
Sub-type Correction/erratum
Volume 1
Issue 4
Start page 309
End page 313
Total pages 5
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Language eng
Abstract Cystic fibrosis (CF) is a fatal genetic disorder hallmarked by chronic and persistent microbial infections of the lungs and airways. Much attention has been paid to describing microbial communities and microbial pathogenesis in CF, however, viral communities have been largely ignored. We recently published a metagenomic study characterizing viral communities in the sputum of CF and Non-CF individuals for the first time. There was a striking difference in metabolic functions encoded by phage in CF versus Non-CF individuals. Regardless of which viral taxa were present, CF-associated phage shared a common core metabolism that reflected the disease state and aberrant airway physiology. Here, this finding is discussed further and its implications for the role of phage and the nature of phage-microbe interactions in the CF airway are explored.
Keyword Cystic fibrosis
Metabolic subsystems
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Addendum to: Willner D, Furlan M, Haynes M, Schmieder R, Angly F, Silva J, et al. Metagenomic analysis of respiratory tract viral communities in cystic fibrosis and non-cystic fibrosis individuals. PLoS ONE 2009; 4:7370; PMID: 19816605; DOI: 10.1371/journal.pone.0007370.

Document type: Journal Article
Sub-type: Correction/erratum
Collections: ERA 2012 Admin Only
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Created: Thu, 20 Oct 2011, 19:03:33 EST by Dana Willner on behalf of School of Chemistry & Molecular Biosciences