Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI

Zang, Yu-Feng, He, Yong, Zhu, Chao-Zhe,, Cao, Qing-Jiu, Sui, Man-Qiu, Liang, Meng, Tian, Li-Xia, Jiang, Tian-Zi and Wang, Yu-Feng (2007) Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain and Development, 29 2: 83-91. doi:10.1016/j.braindev.2006.07.002


Author Zang, Yu-Feng
He, Yong
Zhu, Chao-Zhe,
Cao, Qing-Jiu
Sui, Man-Qiu
Liang, Meng
Tian, Li-Xia
Jiang, Tian-Zi
Wang, Yu-Feng
Title Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
Journal name Brain and Development   Check publisher's open access policy
ISSN 0387-7604
1872-7131
Publication date 2007-03-01
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.braindev.2006.07.002
Open Access Status DOI
Volume 29
Issue 2
Start page 83
End page 91
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Abstract In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01–0.08 Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0 ± 1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, left sensorimotor cortex, and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD.
Keyword Attention deficit hyperactivity disorder
Resting-state functional MRI
Amplitude
Low-frequency fluctuation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 17 August 2006

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 01:56:44 EST by Debra McMurtrie on behalf of Queensland Brain Institute