Strategies for reduction in duration of antibiotic use in hospitalized patients

Hayashi, Yoshiro and Paterson, David L. (2011) Strategies for reduction in duration of antibiotic use in hospitalized patients. Clinical Infectious Diseases, 52 10: 1232-1240. doi:10.1093/cid/cir063

Author Hayashi, Yoshiro
Paterson, David L.
Title Strategies for reduction in duration of antibiotic use in hospitalized patients
Journal name Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1058-4838
Publication date 2011-05-01
Year available 2011
Sub-type Article (original research)
DOI 10.1093/cid/cir063
Open Access Status Not yet assessed
Volume 52
Issue 10
Start page 1232
End page 1240
Total pages 9
Place of publication Cary, NC, U.S.A.
Publisher Oxford University Press
Language eng
Subject 2726 Microbiology (medical)
2725 Infectious Diseases
Abstract There is a global crisis of antibiotic resistance in part because of the collateral damage of antibiotic use. Reduction in antibiotic consumption is clearly important to minimize this problem. Limiting treatment duration may be the most clinically palatable means of reducing antibiotic consumption. Antimicrobial stewardship programs play an important role in this process. Their effectiveness may be increased by drawing on evidence from randomized controlled trials regarding optimal antibiotic duration. However, in most clinical scenarios, the recommended duration of therapy in published guidelines is based on expert opinion. Biological markers, such as procalcitonin, have been shown to reduce antimicrobial consumption with no adverse outcome in 11 randomized controlled trials. Although procalcitonin may not be the perfect biomarker, the concept of procalcitonin-guided antibiotic discontinuation after clinical stabilization, in conjunction with antimicrobial stewardship programs, appears to be ready for introduction into clinical practice.
Keyword Immunology
Infectious Diseases
Infectious Diseases
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 68 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 79 times in Scopus Article | Citations
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Created: Wed, 19 Oct 2011, 22:55:38 EST by Laurie Beechey on behalf of School of Medicine