Dynamic aphasia in progressive supranuclear palsy: A deficit in generating a fluent sequence of novel thought

Robinson, Gail, Shallice, Tim and Cipolotti, Lisa (2006) Dynamic aphasia in progressive supranuclear palsy: A deficit in generating a fluent sequence of novel thought. Neuropsychologia, 44 8: 1344-1360. doi:10.1016/j.neuropsychologia.2006.01.002


Author Robinson, Gail
Shallice, Tim
Cipolotti, Lisa
Title Dynamic aphasia in progressive supranuclear palsy: A deficit in generating a fluent sequence of novel thought
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 0028-3932
1873-3514
Publication date 2006-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2006.01.002
Open Access Status Not Open Access
Volume 44
Issue 8
Start page 1344
End page 1360
Total pages 17
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Formatted abstract
We report a patient (KAS) who presented with pure dynamic aphasia in the context of progressive supranuclear palsy (PSP). KAS had the hallmark propositional language impairment in the context of preserved naming, reading, repetition and comprehension skills. The severity of KAS's propositional language deficit was demonstrated to be comparable to other dynamic aphasic patients. Remarkably, despite virtually abolished propositional speech, KAS was unimpaired on word and sentence level generation tasks that required a single response. This dissociation was further investigated on two discourse level generation tasks that required the generation of multiple connected sentences. Quantitative production analysis and novelty measures demonstrated that her performance was extremely reduced and characterised by a lack of novel words and sentences and a tendency to perseverate. This pattern of performance suggests that there may be two subtypes of dynamic aphasia. Patients with the more documented first subtype have language-specific deficits, fail word and sentence level generation tests and have left inferior frontal gyrus lesions. Patients with the second subtype, like KAS, pass word and sentence level generation tests and fail discourse level generation tests. They have a verbal and non-verbal generation deficit and bilateral frontal and subcortical damage. Our findings are discussed with reference to executive functioning accounts of dynamic aphasia and models of speech production. We interpret our patients’ impairment as being underpinned by a deficit in one set of mechanisms involved in discourse generation; namely the generation of a fluent sequence of novel thought.
Keyword Generation
Initiation
Discourse
Perseveration
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 19 Oct 2011, 20:40:01 EST by Gail Robinson on behalf of School of Psychology