Synthesis and in-vitro bioactivity of mesoporous bioactive glasses with tunable macropores

Wei, Guangfeng, Yan, Xiaoxia, Yi, Jing, Zhao, Lingzhi, Zhou, Liang, Wang, Yunhua and Yu, Chengzhong (2011) Synthesis and in-vitro bioactivity of mesoporous bioactive glasses with tunable macropores. Microporous And Mesoporous Materials, 143 1: 157-165. doi:10.1016/j.micromeso.2011.02.024

Author Wei, Guangfeng
Yan, Xiaoxia
Yi, Jing
Zhao, Lingzhi
Zhou, Liang
Wang, Yunhua
Yu, Chengzhong
Title Synthesis and in-vitro bioactivity of mesoporous bioactive glasses with tunable macropores
Journal name Microporous And Mesoporous Materials   Check publisher's open access policy
ISSN 1387-1811
Publication date 2011-08-01
Sub-type Article (original research)
DOI 10.1016/j.micromeso.2011.02.024
Volume 143
Issue 1
Start page 157
End page 165
Total pages 9
Place of publication Netherlands
Publisher Elsevier BV
Language eng
Abstract By using a nonionic block copolymer surfactant as the mesostructure directing agent, polystyrene (PS) colloidal particles or polyester (Terylene®) fibers as the macropore templates, mesoporous bioactive glass (MBG) materials with tunable macropores in a wide range (0.6-200 μm) have been synthesized and their in vitro bioactivities have been studied. Macro-mesoporous bioactive glass (MMBG) materials obtained by using PS spherical templates have a uniform macropore size of ∼600 nm, while MBG materials synthesized in the presence of terylene fibers have tubular channels (denoted TMBG) with diameters in the range of 8-200 μm adjusted by the diameters of terylene fibers. Both MMBG and TMBG materials have uniform mesopores of ∼5 nm in diameter. Similar to MBG materials, MMBG and TMBG materials have superior in vitro bioactivity compared to conventional bioactive glass. It is also shown that the size of macropore exerts influence on the hydroxycarbonate apatite (HCA) growth behavior within macropores. After soaking MMBG in simulated body fluid, HCA spheres gradually grow to sizes comparable to that of macro-pores after 24 h. While in the case of TMBG, hollow HCA tubes form in the tubular channels of TMBG. It is expected MBG materials with tunable macropores and exceptional in vitro bioactivity may find potential applications in delivery of biological factors, tissue ingrowth, tissue regeneration and neovascularization.
Keyword Bioactive Glass
Tissue engineering
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 18 Oct 2011, 10:22:31 EST by Professor Chengzhong Yu on behalf of Aust Institute for Bioengineering & Nanotechnology