A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Frayling, Timothy M., Timpson, Nicholas J., Weedon, Michael N., Zeggini, Eleftheria, Freathy, Rachel M., Lindgren, Cecilia M., Perry, John R. B., Elliott, Katherine S., Lango, Hana, Rayner, Nigel W., Shields, Beverley, Harries, Lorna W., Barrett, Jeffrey C., Ellard, Sian, Groves, Christopher J., Knight, Bridget, Patch, Ann-Marie, Ness, Andrew R., Ebrahim, Shah, Lawlor, Debbie A., Ring, Susan M., Ben-Shlomo, Yoav, Jarvelin, Marjo-Riitta, Sovio, Ulla, Bennett, Amanda J., Melzer, David, Ferrucci, Luigi, Loos, Ruth J. F., Barroso, Inês, Wareham, Nicholas J., Karpe, Fredrik, Owen, Katharine R., Cardon, Lon R., Walker, Mark, Hitman, Graham A., Palmer, Colin N. A., Doney, Alex S. F.Graham A., Morris, Andrew D., Smith, George Davey, Hattersley, Andrew T., McCarthy, Mark I. and Wellcome Trust Case Control (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316 5826: 889-894. doi:10.1126/science.1141634

Author Frayling, Timothy M.
Timpson, Nicholas J.
Weedon, Michael N.
Zeggini, Eleftheria
Freathy, Rachel M.
Lindgren, Cecilia M.
Perry, John R. B.
Elliott, Katherine S.
Lango, Hana
Rayner, Nigel W.
Shields, Beverley
Harries, Lorna W.
Barrett, Jeffrey C.
Ellard, Sian
Groves, Christopher J.
Knight, Bridget
Patch, Ann-Marie
Ness, Andrew R.
Ebrahim, Shah
Lawlor, Debbie A.
Ring, Susan M.
Ben-Shlomo, Yoav
Jarvelin, Marjo-Riitta
Sovio, Ulla
Bennett, Amanda J.
Melzer, David
Ferrucci, Luigi
Loos, Ruth J. F.
Barroso, Inês
Wareham, Nicholas J.
Karpe, Fredrik
Owen, Katharine R.
Cardon, Lon R.
Walker, Mark
Hitman, Graham A.
Palmer, Colin N. A.
Doney, Alex S. F.Graham A.
Morris, Andrew D.
Smith, George Davey
Hattersley, Andrew T.
McCarthy, Mark I.
Wellcome Trust Case Control
Title A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 2007-05-11
Sub-type Article (original research)
DOI 10.1126/science.1141634
Open Access Status Not yet assessed
Volume 316
Issue 5826
Start page 889
End page 894
Total pages 6
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Abstract Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
Keyword Fused Toes Ft
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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