Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein

Raju, Ritesh, Piggott, Andrew M., Huang, Xiao-Cong and Capon, Robert J. (2011) Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein. Organic Letters, 13 10: 2770-2773. doi:10.1021/ol200904v


Author Raju, Ritesh
Piggott, Andrew M.
Huang, Xiao-Cong
Capon, Robert J.
Title Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7052
1523-7060
Publication date 2011-05-20
Sub-type Article (original research)
DOI 10.1021/ol200904v
Open Access Status Not Open Access
Volume 13
Issue 10
Start page 2770
End page 2773
Total pages 4
Place of publication Washington, DC, U.S.A.
Publisher American Chemical Society
Language eng
Formatted abstract
An Australian marine sediment-derived isolate, Nocardiopsis sp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell.
Keyword Streptomyces Sp
A-D
Actinomycete
Alkaloids
Fungus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 50 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 53 times in Scopus Article | Citations
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Created: Fri, 14 Oct 2011, 04:48:15 EST by Professor Robert Capon on behalf of Institute for Molecular Bioscience