Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex Development of Selective RabGGTase Inhibitors and Crystal Structure of a RabGGTase–Inhibitor Complex

Guo, Zhong, Wu, Yao-Wen, Tan, Kui-Thong, Bon, Robin S., Guiu-Rozas, Ester, Delon, Christine, Nguyen, Uyen T., Wetzel, Stefan, Arndt, Sabine, Goody, Roger S., Blankenfeldt, Wulf, Alexandrov, Kirill and Waldmann, Herbert (2008) Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex Development of Selective RabGGTase Inhibitors and Crystal Structure of a RabGGTase–Inhibitor Complex. Angewandte Chemie (International Edition), 47 20: 3747-3750. doi:10.1002/anie.200705795


Author Guo, Zhong
Wu, Yao-Wen
Tan, Kui-Thong
Bon, Robin S.
Guiu-Rozas, Ester
Delon, Christine
Nguyen, Uyen T.
Wetzel, Stefan
Arndt, Sabine
Goody, Roger S.
Blankenfeldt, Wulf
Alexandrov, Kirill
Waldmann, Herbert
Title Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex Development of Selective RabGGTase Inhibitors and Crystal Structure of a RabGGTase–Inhibitor Complex
Journal name Angewandte Chemie (International Edition)   Check publisher's open access policy
ISSN 1433-7851
1521-3773
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/anie.200705795
Open Access Status Not Open Access
Volume 47
Issue 20
Start page 3747
End page 3750
Total pages 4
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Formatted abstract
Stopping the transfer: Based on the structure of pepticinnamin E, specific inhibitors of Rab geranylgeranyl transferase (RabGGTase) with activity in cells were developed, and the first crystal structure of the enzyme in complex with an inhibitor is reported (see inhibitor structure and positioning in the active site of the enzyme). The findings may have implications for the chemical-biological study of Rab prenylation and vesicular transport and the involvement of RabGGTase in the establishment of disease. (Chemical Equation Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Keyword Inhibitors
Prenylation
Protein modifications
Protein Structures
Transferases
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This article also published in Angewandte Chemie: Volume 120, Issue 20, pages 3807–3810, May 5, 2008 ISSN: 0044-8249;1521-3757, DOI: 10.1002/ange.200705795

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 14 Oct 2011, 02:03:28 EST by Zhong Guo on behalf of Institute for Molecular Bioscience