Tmem26 is dynamically expressed during palate and limb development but is not required for embryonic survival

Town, Liam, McGlinn, Edwina, Davidson, Tara-Lynne, Browne, Catherine M., Chawengsaksophak, Kallayanee, Koopman, Peter, Richman, Joy M. and Wicking, Carol (2011) Tmem26 is dynamically expressed during palate and limb development but is not required for embryonic survival. PLoS One, 6 9: e25228-1-e25228-9. doi:10.1371/journal.pone.0025228


Author Town, Liam
McGlinn, Edwina
Davidson, Tara-Lynne
Browne, Catherine M.
Chawengsaksophak, Kallayanee
Koopman, Peter
Richman, Joy M.
Wicking, Carol
Title Tmem26 is dynamically expressed during palate and limb development but is not required for embryonic survival
Formatted title
Tmem26 is dynamically expressed during palate and limb development but is not required for embryonic survival
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2011-09-01
Year available 2011
Sub-type Article (original research)
DOI 10.1371/journal.pone.0025228
Open Access Status DOI
Volume 6
Issue 9
Start page e25228-1
End page e25228-9
Total pages 9
Place of publication San Francisco, CA, United Sates
Publisher Public Library of Science
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract The Tmem26 gene encodes a novel protein that we have previously shown to be regulated by hedgehog signalling in the mouse limb. We now report that Tmem26 expression is spatially and temporally restricted in other regions of the mouse embryo, most notably the facial primordia. In particular, Tmem26 expression in the mesenchyme of the maxillary and nasal prominences is coincident with fusion of the primary palate. In the secondary palate, Tmem26 is expressed in the palatal shelves during their growth and fusion but is downregualted once fusion is complete. Expression was also detected at the midline of the expanding mandible and at the tips of the eyelids as they migrate across the cornea. Given the spatio-temporally restricted expression of Tmen26, we sought to uncover a functional role in embryonic development through targeted gene inactivation in the mouse. However, ubiquitous inactivation of Tmem26 led to no overt phenotype in the resulting embryos or adult mice, suggesting that TMEM26 function is dispensable for embryonic survival.
Formatted abstract
The Tmem26 gene encodes a novel protein that we have previously shown to be regulated by hedgehog signalling in the mouse limb. We now report that Tmem26 expression is spatially and temporally restricted in other regions of the mouse embryo, most notably the facial primordia. In particular, Tmem26 expression in the mesenchyme of the maxillary and nasal prominences is coincident with fusion of the primary palate. In the secondary palate, Tmem26 is expressed in the palatal shelves during their growth and fusion but is downregulated once fusion is complete. Expression was also detected at the midline of the expanding mandible and at the tips of the eyelids as they migrate across the cornea. Given the spatio-temporally restricted expression of Tmem26, we sought to uncover a functional role in embryonic development through targeted gene inactivation in the mouse. However, ubiquitous inactivation of Tmem26 led to no overt phenotype in the resulting embryos or adult mice, suggesting that TMEM26 function is dispensable for embryonic survival.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
MULTIDISCIPLINARY SCIENCES
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 401683
Institutional Status UQ

 
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Created: Thu, 13 Oct 2011, 23:36:05 EST by Carol Wicking on behalf of School of Biomedical Sciences