Cell cycle control of germ cell differentiation

Spiller, Cassy M. and Koopman, Peter (2011). Cell cycle control of germ cell differentiation. In Jacek Z. Kubiak (Ed.), Cell cycle in development (pp. 269-308) New York, United States: Springer. doi:10.1007/978-3-642-19065-0

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Author Spiller, Cassy M.
Koopman, Peter
Title of chapter Cell cycle control of germ cell differentiation
Title of book Cell cycle in development
Language of Book Title eng
Place of Publication New York, United States
Publisher Springer
Publication Year 2011
Sub-type Research book chapter (original research)
DOI 10.1007/978-3-642-19065-0
Open Access Status Not yet assessed
Year available 2011
Series Results and Problems in Cell Differentiation
ISBN 9783642190650
ISSN 0080-1844
Editor Jacek Z. Kubiak
Volume number 53
Chapter number 13
Start page 269
End page 308
Total pages 40
Total chapters 23
Language eng
Abstract/Summary The germ cell lineage is our lifelong reservoir of reproductive stem cells and our mechanism for transmitting genes to future generations. These highly specialised cells are specified early during development and then migrate to the embryonic gonads where sex differentiation occurs. Germ cell sex differentiation is directed by the somatic gonadal environment and is characterised by two distinct cell cycle states that are maintained until after birth. In the mouse, XY germ cells in a testis cease mitotic proliferation and enter G1/G0 arrest from 12.5 dpc, while XX germ cells in an ovary enter prophase I of meiosis from 13.5 dpc. This chapter discusses the factors known to control proliferation and survival of germ cells during their journey of specification to sex differentiation during development.
Keyword Leukemia Inhibitory Factor
Embryonic Stem-Cells
Neonatal-Rat Testis
Tissue-Specific Regulation
Gene-Expression Patterns
Tumor-Suppressor Protein
Retinoic Acid Receptors
X-Chromosome Activity
Mouse Fetal Gonads
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Figures,Plates,Color plates

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Created: Thu, 13 Oct 2011, 22:33:10 EST by Cassy Spiller on behalf of Institute for Molecular Bioscience