Ion Channels and the Signal-Transduction Pathways in the Regulation of Growth-Hormone Secretion

Chen, C, Vincent, JD and Clarke, IJ (1994) Ion Channels and the Signal-Transduction Pathways in the Regulation of Growth-Hormone Secretion. Trends in Endocrinology and Metabolism, 5 6: 227-233. doi:10.1016/1043-2760(94)P3080-Q


Author Chen, C
Vincent, JD
Clarke, IJ
Title Ion Channels and the Signal-Transduction Pathways in the Regulation of Growth-Hormone Secretion
Journal name Trends in Endocrinology and Metabolism   Check publisher's open access policy
ISSN 1043-2760
Publication date 1994-08-01
Year available 1994
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/1043-2760(94)P3080-Q
Open Access Status Not yet assessed
Volume 5
Issue 6
Start page 227
End page 233
Total pages 7
Place of publication NEW YORK
Publisher ELSEVIER SCIENCE INC
Language eng
Abstract The secretion of GH from pituitary somatotrophs is mainly regulated by alterations in the levels of intracellular free Ca2+ concentrations ([Ca2+](i)) that depend on the influx of Ca2+ through voltage-gated Ca2+ channels in the cell membrane. Hypothalamic stimulatory and inhibitory factors bind to specific receptors on the cell membrane to regulate membrane potential and activate second-messenger systems. The receptors are G-protein coupled, and activated G proteins directly influence membrane ion channels to regulate Ca2+ influx. The function of cAMP-dependent protein kinase A is also modulated by receptor-coupled G proteins leading to the phosphorylation of Ca2+ channel proteins and further alteration of Ca2+ influx.
Keyword Intracellular Free Calcium
Anterior-Pituitary-Cells
Dependent Protein-Kinase
Amp-Independent Actions
Sensitive K+ Channels
Chick Sensory Neurons
Cyclic-Amp
Rat Somatotrophs
Somatostatin Receptors
Electrophysiological Responses
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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