Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules

Georgas, K. M., Chiu, H. S., Lesieur, E., Rumballe, B. A. and Little, Melissa H. (2011) Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Developmental Dynamics, 240 6: 1600-1612. doi:10.1002/dvdy.22640

Author Georgas, K. M.
Chiu, H. S.
Lesieur, E.
Rumballe, B. A.
Little, Melissa H.
Title Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules
Journal name Developmental Dynamics   Check publisher's open access policy
ISSN 1058-8388
Publication date 2011-06-01
Year available 2011
Sub-type Article (original research)
DOI 10.1002/dvdy.22640
Open Access Status
Volume 240
Issue 6
Start page 1600
End page 1612
Total pages 3
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
The metanephros is the functional organ in adult amniotes while the mesonephros degenerates. However, parallel tubulogenetic events are thought to exist between mesonephros and metanephros. Mesonephric tubules are retained in males and differentiate into efferent ducts of the male reproductive tract. By examining the murine mesonephric expression of markers of distinct stages and regions of metanephric nephrons during tubule formation and patterning, we provide further evidence to support this common morphogenetic mechanism. Renal vesicle, early proximal and distal tubule, loop of Henle, and renal corpuscle genes were expressed by mesonephric tubules. Vip, Slc6a20b, and Slc18a1 were male-specific. In contrast, mining of the GUDMAP database identified candidate late mesonephros-specific genes, 10 of which were restricted to the male. Among the male-specific genes are candidates for regulating ion/fluid balance within the efferent ducts, thereby regulating sperm maturation and genes marking tubule-associated neurons potentially critical for normal male reproductive tract function.
Keyword Mesonephros
Gene expression
Efferent duct
Male reproductive tract
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DK070136
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 11 Oct 2011, 01:25:44 EST by Kylie Georgas on behalf of Institute for Molecular Bioscience