Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR

Mobli, Mehdi, Morgenstern, David, King, Glenn F., Alewood, Paul F. and Muttenthaler, Markus (2011) Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR. Angewandte Chemie (International Edition), 50 50: 11952-11955. doi:10.1002/anie.201104169


Author Mobli, Mehdi
Morgenstern, David
King, Glenn F.
Alewood, Paul F.
Muttenthaler, Markus
Title Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR
Formatted title
Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR
Journal name Angewandte Chemie (International Edition)   Check publisher's open access policy
ISSN 1433-7851
1521-3773
Publication date 2011-12-09
Year available 2011
Sub-type Article (original research)
DOI 10.1002/anie.201104169
Open Access Status Not yet assessed
Volume 50
Issue 50
Start page 11952
End page 11955
Total pages 4
Place of publication Weinheim, Germany
Publisher Wiley - V C H
Language eng
Formatted abstract
Selenocysteine (Sec), the 21st amino acid, is a component of a variety of proteins in all lineages of life, and the greater acidity of selenols compared to thiols provides Sec with unique chemical properties. By using 77Se NMR spectroscopy the pKa of Sec residues in a protein could be measured at atomic resolution. This information can be used to predict chemical reactions.
Keyword NMR spectroscopy
pKa values
Selective alkylation
Selenocysteine
Selenovasopressin
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP1095728
Institutional Status UQ
Additional Notes This work was supported by Discovery Grant DP1095728 from the Australian Research Council and the Internationally Outgoing Marie Curie Fellowship.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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Created: Sat, 08 Oct 2011, 00:16:20 EST by Professor Glenn King on behalf of School of Chemistry & Molecular Biosciences