Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic

Vercruysse, Jozef, Behnke, Jerzy M., Albonico, Marco, Ame, Shaali Makame, Angebault, Cecile, Bethony, Jeffrey M., Engels, Dirk, Guillard, Bertrand, Hoa, Nguyen Thi Viet, Kang, Gagandeep, Kattula, Deepthi, Kotze, Andrew C., McCarthy, James S., Mekonnen, Zeleke, Montresor, Antonio, Periago, Maria Victoria, Sumo, Laurentine, Tchuente, Louis-Albert Tchuem, Thach, Dang Thi Cam, Zeynudin, Ahmed and Levecke, Bruno (2011) Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic. PLoS Neglected Tropical Diseases, 5 3: e948-1-e948-10. doi:10.1371/journal.pntd.0000948


Author Vercruysse, Jozef
Behnke, Jerzy M.
Albonico, Marco
Ame, Shaali Makame
Angebault, Cecile
Bethony, Jeffrey M.
Engels, Dirk
Guillard, Bertrand
Hoa, Nguyen Thi Viet
Kang, Gagandeep
Kattula, Deepthi
Kotze, Andrew C.
McCarthy, James S.
Mekonnen, Zeleke
Montresor, Antonio
Periago, Maria Victoria
Sumo, Laurentine
Tchuente, Louis-Albert Tchuem
Thach, Dang Thi Cam
Zeynudin, Ahmed
Levecke, Bruno
Title Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic
Journal name PLoS Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2727
Publication date 2011-03-01
Sub-type Article (original research)
DOI 10.1371/journal.pntd.0000948
Open Access Status DOI
Volume 5
Issue 3
Start page e948-1
End page e948-10
Total pages 10
Place of publication San Francisco, CA, U.S.A.
Publisher Public Library of Science
Language eng
Abstract Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugs in preventive chemotherapy (PC) programs for controlling soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura, and hookworm) are still lacking. However, they are urgently needed to ensure detection of reduced efficacies that are predicted to occur due to growing drug pressure. Here, using a standardized methodology, we assessed the FECR rate of a single oral dose of mebendazole (MEB; 500 mg) against STHs in six trials in school children in different locations around the world. Our results are compared with those previously obtained for similarly conducted trials of a single oral dose of albendazole (ALB; 400 mg).
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 001
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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Created: Mon, 03 Oct 2011, 23:25:14 EST by Matthew Lamb on behalf of School of Medicine