Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex

Smith, Margaret J., Sharples, Robyn A., Evin, Genevieve, McLean, Catriona A., Dean, Brian, Pavey, Geoff, Fantino, Emmanuelle, Cotton, Richard G. H., Imaizumi, Kazunori, Masters, Colin L., Cappai, Roberto and Culvenor, Janetta G. (2004) Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex. Molecular Brain Research, 127 1-2: 128-135. doi:10.1016/j.molbrainres.2004.05.019


Author Smith, Margaret J.
Sharples, Robyn A.
Evin, Genevieve
McLean, Catriona A.
Dean, Brian
Pavey, Geoff
Fantino, Emmanuelle
Cotton, Richard G. H.
Imaizumi, Kazunori
Masters, Colin L.
Cappai, Roberto
Culvenor, Janetta G.
Title Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
Journal name Molecular Brain Research   Check publisher's open access policy
ISSN 0169-328X
1872-6941
Publication date 2004-08-01
Sub-type Article (original research)
DOI 10.1016/j.molbrainres.2004.05.019
Volume 127
Issue 1-2
Start page 128
End page 135
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract We have analysed the expression of a truncated variant presenilin 2 protein (PS2V) in frontal cortex from subjects with Alzheimer's disease (AD) and age-matched controls, and compared these results with cortex from bipolar disorder (BP), schizophrenia (SZ) and controls in a second brain bank collection. PS2V protein was detected as a 14 kDa species with antibodies directed to the PS2 N-terminal region and to the new C-terminus created by alternative transcription. PS2V protein levels were significantly increased by two-fold in AD cortex, as compared to age-matched controls. In tissue from the second collection, levels of PS2V were markedly elevated in some BP and SZ cases, but there was no overall difference between diagnostic groups. Our findings support previous evidence for increased expression of this variant PS2 isoform in sporadic AD and suggest this isoform may contribute to neurodegeneration.
Keyword AD
Alzheimer's disease
BCA
Bicinchoninic acid
Bipolar disorder
Degenerative disease
Schizophrenia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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