Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)

Burns, Christopher J., Bourke, David G., Andrau, Laura, Bu, Xianyong, Charman, Susan A., Donohue, Andrew C., Fantino, Emmanuelle, Farrugia, Michelle, Feutrill, John T., Joffe, Max, Kling, Marcel R., Kurek, Margarita, Nero, Tracy L., Nguyen, Thao, Palmer, James T., Phillips, Ian, Shackleford, David M, Sikanyika, Harrison, Styles, Michelle, Su, Stephen, Treutlein, Herbert, Zeng, Jun and Wilks, Andrew F. (2009) Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs). Bioorganic & Medicinal Chemistry Letters, 19 20: 5887-5892. doi:10.1016/j.bmcl.2009.08.071

Author Burns, Christopher J.
Bourke, David G.
Andrau, Laura
Bu, Xianyong
Charman, Susan A.
Donohue, Andrew C.
Fantino, Emmanuelle
Farrugia, Michelle
Feutrill, John T.
Joffe, Max
Kling, Marcel R.
Kurek, Margarita
Nero, Tracy L.
Nguyen, Thao
Palmer, James T.
Phillips, Ian
Shackleford, David M
Sikanyika, Harrison
Styles, Michelle
Su, Stephen
Treutlein, Herbert
Zeng, Jun
Wilks, Andrew F.
Title Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)
Journal name Bioorganic & Medicinal Chemistry Letters   Check publisher's open access policy
ISSN 0960-894X
Publication date 2009-10-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.bmcl.2009.08.071
Open Access Status Not yet assessed
Volume 19
Issue 20
Start page 5887
End page 5892
Total pages 6
Place of publication Kidlington, Oxford, U. K.
Publisher Pergamon
Language eng
Formatted abstract
A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide). Details of synthesis and SAR studies of these compounds are reported. © 2009 Elsevier Ltd. All rights reserved.
Keyword Jak2
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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