Ultrastructure of the Rat Pancreas After Experimental Duct Ligation .2. Duct and Stromal Cell-Proliferation, Differentiation, and Deletion

Walker, NI, Winterford, CM and Kerr, Jfr (1992) Ultrastructure of the Rat Pancreas After Experimental Duct Ligation .2. Duct and Stromal Cell-Proliferation, Differentiation, and Deletion. Pancreas, 7 4: 420-434. doi:10.1097/00006676-199207000-00002


Author Walker, NI
Winterford, CM
Kerr, Jfr
Title Ultrastructure of the Rat Pancreas After Experimental Duct Ligation .2. Duct and Stromal Cell-Proliferation, Differentiation, and Deletion
Journal name Pancreas   Check publisher's open access policy
ISSN 0885-3177
Publication date 1992-07-01
Year available 1992
Sub-type Article (original research)
DOI 10.1097/00006676-199207000-00002
Open Access Status DOI
Volume 7
Issue 4
Start page 420
End page 434
Total pages 15
Place of publication PHILADELPHIA
Publisher LIPPINCOTT-RAVEN PUBL
Language eng
Abstract Ligation of the pancreas in rats was followed by rapid atrophy of the distal part of the gland, where deletion of the acinar cells by apoptosis and simultaneous extensive proliferation of duct cells resulted in the lobules being converted into groups of closely packed small ducts within 5 days. We found no ultrastructural evidence that cells lining these small ducts arose from acinar cells by a process of dedifferentiation, as has been suggested by some investigators. During the succeeding weeks, some of the ductal lining cells developed islet cell or partial acinar cell differentiation. The latter soon died by apoptosis, and some ductlike and islet cells were also deleted by this means. Most of the apoptotic bodies formed in the ducts were phagocytosed by intraepithelial macrophages. In the longer term, continuing apoptosis eventually resulted in the disappearance of many ducts, only their thickened basal laminae remaining. Differentiation of stromal fibroblasts into contractile myofibroblasts may have contributed to shrinkage of the duct-obstructed glandular tissue, and apoptosis of endothelial cells probably accounted for the associated reduction of the capillary bed.
Keyword Apoptosis
Atrophy
Cell Proliferation
Differentiation
Duct Ligation
Pancreas
Ultrastructure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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