Vitamin D metabolism and deficiency in critical illness

Lee, Paul (2011) Vitamin D metabolism and deficiency in critical illness. Best Practice and Research: Clinical Endocrinology and Metabolism, 25 5: 769-781. doi:10.1016/j.beem.2011.03.001


Author Lee, Paul
Title Vitamin D metabolism and deficiency in critical illness
Journal name Best Practice and Research: Clinical Endocrinology and Metabolism   Check publisher's open access policy
ISSN 1878-1594
Publication date 2011-10-01
Sub-type Article (original research)
DOI 10.1016/j.beem.2011.03.001
Open Access Status DOI
Volume 25
Issue 5
Start page 769
End page 781
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Bailliere Tindall
Language eng
Subject 1310 Endocrinology
2712 Endocrinology, Diabetes and Metabolism
Abstract Vitamin D deficiency is highly prevalent and has been associated with a diverse range of chronic medical conditions in the general population. In contrast, the prevalence, pathogenesis and significance of vitamin D deficiency have received little attention in acute medicine. Vitamin D deficiency is seldom considered and rarely corrected adequately, if at all, in critically ill patients. Recent recognition of the extra-skeletal, pleiotropic actions of vitamin D in immunity, epithelial function and metabolic regulation may underlie the previously under-recognized contribution of vitamin D deficiency to typical co-morbidities in critically ill patients, including sepsis, systemic inflammatory response syndrome and metabolic dysfunction. Improved understanding of vitamin D metabolism and regulation in critical illness may allow therapeutic exploitation of vitamin D to improve outcome in critically ill patients.
Keyword Vitamin D
Critical illness
Parathyroid hormone
Hypocalcaemia
Hyperparathyroidism
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Issue theme: Endocrine Management in the Intensive Care Unit

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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Created: Sun, 25 Sep 2011, 07:19:33 EST by Paul Lee on behalf of Medicine - Princess Alexandra Hospital