Catheter-associated bloodstream infection incidence and risk factors in adults with cancer: A prospective cohort study

Mollee, P., Jones, M., Stackelroth, J., van Kuilenburg, R., Joubert, W., Faoagali, J., Looke, D., Harper, J. and Clements, A. (2011) Catheter-associated bloodstream infection incidence and risk factors in adults with cancer: A prospective cohort study. Journal of Hospital Infection, 78 1: 26-30. doi:10.1016/j.jhin.2011.01.018

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Faoagali_Joan_authaffil_staffdata.pdf Faoagali_Joan_authaffil_staffdata.pdf application/pdf 150.33KB 0
Looke_David_authoraffil_staffdata.pdf Looke_David_authoraffil_staffdata.pdf application/pdf 247.45KB 0
Mollee_Peter_authoraffil_staffdata.pdf Mollee_Peter_authoraffil_staffdata.pdf application/pdf 224.31KB 0

Author Mollee, P.
Jones, M.
Stackelroth, J.
van Kuilenburg, R.
Joubert, W.
Faoagali, J.
Looke, D.
Harper, J.
Clements, A.
Title Catheter-associated bloodstream infection incidence and risk factors in adults with cancer: A prospective cohort study
Journal name Journal of Hospital Infection   Check publisher's open access policy
ISSN 0195-6701
1532-2939
Publication date 2011-05-01
Sub-type Article (original research)
DOI 10.1016/j.jhin.2011.01.018
Volume 78
Issue 1
Start page 26
End page 30
Total pages 5
Place of publication Camden, London, U.K.
Publisher W.B. Saunders
Collection year 2012
Language eng
Formatted abstract
Central venous catheter-associated bloodstream infections (CABSIs) cause considerable morbidity in patients with cancer. We determined the incidence and risk factors for CABSI by performing a prospective observational cohort study of all adult patients requiring a central venous access device (CVAD) in a haematology–oncology unit. All CVADs were inserted under ultrasound guidance by trained operators in a dedicated interventional radiology facility. A total of 1127 CVADs were assessed in 727 patients over 51 514 line-days. The rate of CABSI per 1000 line-days was 2.50. Factors associated with CABSI included: type of CVAD, greatest for non-tunnelled lines [hazard ratio (HR): 3.50; P < 0.0001] and tunnelled lines (HR: 1.77; P = 0.011) compared to peripherally inserted central venous catheter (PICC) lines; patient diagnosis, greatest for aggressive haematological malignancies (HR: 3.17; P = 0.0007) and least for oesophageal, colon and rectal cancers (HR: 0.29; P = 0.019) compared to other solid tumours; side of insertion, greatest for right-sided lines (HR: 1.60; P = 0.027); and number of prior line insertions (HR: 1.20; P = 0.022). In patients with aggressive haematological malignancies there was significantly more CABSI with non-tunnelled lines (HR: 3.9; P < 0.001) and a trend to more CABSI with tunnelled lines (HR: 1.43; P = 0.12) compared to patients with PICC lines, as well as increased CABSI for right-sided insertions (HR: 1.62; P = 0.047). This study highlights the utility of a standardised CABSI surveillance strategy in adult patients with cancer, provides further data to support the use of PICC lines in such patient populations, and suggests that the side of line insertion may influence risk of CABSI.
Keyword Catheter-associated bloodstream infection
Cancer
Central line
Central venous catheters
Hospitalized-patients
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
School of Medicine Publications
 
Available Versions of this Record
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 58 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 23 Sep 2011, 21:15:34 EST by Geraldine Fitzgerald on behalf of School of Medicine