Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR)

Skeldal, Sune, Matusica, Dusan, Nykjaer, Anders and Coulson, Elizabeth J. (2011) Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR). BioEssays, 33 8: 614-625. doi:10.1002/bies.201100036


Author Skeldal, Sune
Matusica, Dusan
Nykjaer, Anders
Coulson, Elizabeth J.
Title Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR)
Formatted title
Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75 NTR
Journal name BioEssays   Check publisher's open access policy
ISSN 0265-9247
Publication date 2011-08-01
Year available 2011
Sub-type Article (original research)
DOI 10.1002/bies.201100036
Open Access Status Not yet assessed
Volume 33
Issue 8
Start page 614
End page 625
Total pages 12
Place of publication United Kingdom
Publisher John Wiley & Sons Ltd.
Language eng
Abstract The common neurotrophin receptor (p75(NTR)) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of the cell cycle can be regulated by p75(NTR)-mediated signals following activation by either mature or pro-neurotrophins and in combination with various co-receptors, including Trk receptors and sortilin. Here, we review the known functions of p75(NTR) by cell type, receptor-ligand combination, and whether regulated intra-membrane proteolysis of p75(NTR) is required for signalling. We highlight that the generation of the intracellular domain fragment of p75(NTR) is associated with many of the receptor functions, regardless of its ligand and co-receptor interactions.
Formatted abstract
The common neurotrophin receptor (p75NTR) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of the cell cycle can be regulated by p75NTR-mediated signals following activation by either mature or pro-neurotrophins and in combination with various co-receptors, including Trk receptors and sortilin. Here, we review the known functions of p75NTR by cell type, receptor-ligand combination, and whether regulated intra-membrane proteolysis of p75NTR is required for signalling. We highlight that the generation of the intracellular domain fragment of p75NTR is associated with many of the receptor functions, regardless of its ligand and co-receptor interactions.
Keyword Neuronal cell death
Neuronal cell survival
P75NTR
Sortilin
Trk receptors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
 
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Created: Thu, 22 Sep 2011, 18:25:23 EST by Dusan Matusica on behalf of Queensland Brain Institute