Simplifying paediatric immunization with a fully liquid DTP-HepB-Hib combination vaccine: Evidence from a comparative time-motion study in India

Wiedenmayer, Karin A., Weiss, Svenja, Chattopadhyay, Chandon, Mukherjee, Ajoy, Kundu, Ritabrata, Ayé, Raffael, Tediosi, Fabrizio, Hetzel, Manuel W. and Tanner, Marcel (2009) Simplifying paediatric immunization with a fully liquid DTP-HepB-Hib combination vaccine: Evidence from a comparative time-motion study in India. Vaccine, 27 5: 655-659. doi:10.1016/j.vaccine.2008.11.045


Author Wiedenmayer, Karin A.
Weiss, Svenja
Chattopadhyay, Chandon
Mukherjee, Ajoy
Kundu, Ritabrata
Ayé, Raffael
Tediosi, Fabrizio
Hetzel, Manuel W.
Tanner, Marcel
Title Simplifying paediatric immunization with a fully liquid DTP-HepB-Hib combination vaccine: Evidence from a comparative time-motion study in India
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
1873-2518
Publication date 2009-01-29
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2008.11.045
Open Access Status Not Open Access
Volume 27
Issue 5
Start page 655
End page 659
Total pages 5
Place of publication Oxford, U.K.
Publisher Elsevier
Language eng
Formatted abstract
An observational time-motion study investigated logistic, programmatic and safety-related advantages and limits in the delivery of a fully liquid DTP–HepB–Hib combination vaccine versus a lyophilized combination vaccine requiring reconstitution. The study was conducted in 2006, observing 312 child vaccinations in a tertiary hospital setting in Kolkata, India. The time for vaccination was on average 46 s (35.12%) lower with the fully liquid vaccine (p < 0.05). In addition, the fully liquid combination was easier and potentially safer to handle and as well tolerated as the lyophilized formulation. Fully liquid combination vaccines have the potential to simplify immunization schedules, contribute to better resource management and improve efficiency of immunization programs.
Keyword Time-motion study
Pentavalent vaccine
Childhood vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 3 December 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 21 Sep 2011, 09:20:25 EST by Dr Manuel Hetzel on behalf of School of Public Health