The effect of pain on training-induced plasticity of the corticomotor system

Ingham, Damian, Tucker, Kylie J., Tsao, Henry and Hodges, Paul W. (2011) The effect of pain on training-induced plasticity of the corticomotor system. European Journal of Pain, 15 10: 1028-1034. doi:10.1016/j.ejpain.2011.04.006

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Author Ingham, Damian
Tucker, Kylie J.
Tsao, Henry
Hodges, Paul W.
Title The effect of pain on training-induced plasticity of the corticomotor system
Journal name European Journal of Pain   Check publisher's open access policy
ISSN 1090-3801
1532-2149
Publication date 2011-11-01
Sub-type Article (original research)
DOI 10.1016/j.ejpain.2011.04.006
Volume 15
Issue 10
Start page 1028
End page 1034
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2012
Language eng
Abstract Pain is thought to interfere with training-induced plasticity of corticomotor pathways. Although this implies direct interference with plastic processes, it may be explained by compromised performance in the training task during pain. Repeated finger movements can induce plasticity and change the amplitude/direction of acceleration of finger movement evoked by transcranial magnetic stimulation (TMS). We hypothesized that if pain interferes with plasticity, acceleration of finger movement would not change when the training task was painful, despite control of training task performance. TMS was applied over the optimal scalp site to evoked index finger abduction movements in nine participants. Participants then trained finger adduction with feedback of finger acceleration for three 8-min sessions, in three conditions on separate days. Conditions: first dorsal interosseus (FDI) pain and control (no-pain), with injection of 5% and 0.9% hypertonic saline, respectively, into FDI; and remote pain (5% saline injection into infrapatellar fat pad). Peak acceleration of TMS-evoked finger movement and amplitude of motor evoked potentials (MEPs) in FDI were measured at baseline, between training sessions, and at three 5-min intervals after training ceased. Plastic change was observed (reduced TMS evoked peak finger acceleration in the abduction direction) after motor training during control and FDI pain, but not during the remote pain. There was no change in FDI MEPs in any conditions. These data do not support direct effects of nociceptive input (pain) on training-induced plasticity of corticomotor pathways. Remote pain may compromise learning due to distraction from the training task or other complex central pain processes.
Keyword Pain
Motor control
Motor evoked potential
Motor learning
Training
Attention
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Health and Rehabilitation Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 20 Sep 2011, 23:00:48 EST by Ms Kylie Tucker on behalf of School of Health & Rehabilitation Sciences