Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses

Alikhan, Maliha A., Jones, Christina V., Williams, Timothy M., Beckhouse, Anthony G., Fletcher , Anne L., Kett, Michelle M., Sakkal, Samy, Samuel, Chrishan S., Ramsay, Robert G., Deane, James A., Wells, Christine A., Little, Melissa H., Hume, David A. and Ricardo, Sharon D. (2011) Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. The American Journal of Pathology, 179 3: 1243-1256. doi:10.1016/j.ajpath.2011.05.037


Author Alikhan, Maliha A.
Jones, Christina V.
Williams, Timothy M.
Beckhouse, Anthony G.
Fletcher , Anne L.
Kett, Michelle M.
Sakkal, Samy
Samuel, Chrishan S.
Ramsay, Robert G.
Deane, James A.
Wells, Christine A.
Little, Melissa H.
Hume, David A.
Ricardo, Sharon D.
Title Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses
Journal name The American Journal of Pathology   Check publisher's open access policy
ISSN 0002-9440
1525-2191
Publication date 2011-09-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.ajpath.2011.05.037
Open Access Status Not Open Access
Volume 179
Issue 3
Start page 1243
End page 1256
Total pages 14
Place of publication Bethesda, MD, United States
Publisher American Society for Investigative Pathology
Language eng
Abstract Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney weight and volume and was associated with increased numbers of tissue macrophages. Moreover, CSF-1 promotes postnatal renal repair in mice after ischemia-reperfusion injury by recruiting and influencing macrophages toward a reparative state. CSF-1 treatment rapidly accelerated renal repair with tubular epithelial cell replacement, attenuation of interstitial fibrosis, and functional recovery. Analysis of macrophages from CSF-1-treated kidneys showed increased expression of insulin-like growth factor-1 and anti-inflammatory genes that are known CSF-1 targets. Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury.
Keyword Pathology
Pathology
PATHOLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Issue section: "Cell Injury, Repair, Aging, and Apoptosis"

 
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Created: Tue, 20 Sep 2011, 22:42:31 EST by Dr Anthony Beckhouse on behalf of Aust Institute for Bioengineering & Nanotechnology