DR-D2 Taq1a polymorphisms are associated with personality traits that correlate with alcohol craving in alcohol-dependent subjects

Ho, A. M., Daglish, M., Dodd, P. R. and Stadlin, A. (2011). DR-D2 Taq1a polymorphisms are associated with personality traits that correlate with alcohol craving in alcohol-dependent subjects. In: Abstracts of ESBRA 2011, European Society for Biomedical Research on Alcoholism. ESBRA 2011, European Society for Biomedical Research on Alcoholism, Vienna, Austria, (48-48). September 4-7 2011. doi:10.1093/alcalc/agr119


Author Ho, A. M.
Daglish, M.
Dodd, P. R.
Stadlin, A.
Title of paper DR-D2 Taq1a polymorphisms are associated with personality traits that correlate with alcohol craving in alcohol-dependent subjects
Formatted title
DR-D2 Taq1a polymorphisms are associated with personality traits that correlate with alcohol craving in alcohol-dependent subjects
Conference name ESBRA 2011, European Society for Biomedical Research on Alcoholism
Conference location Vienna, Austria
Conference dates September 4-7 2011
Proceedings title Abstracts of ESBRA 2011, European Society for Biomedical Research on Alcoholism   Check publisher's open access policy
Journal name Alcohol and Alcoholism   Check publisher's open access policy
Place of Publication Oxford, United Kingdom
Publisher Oxford University Press
Publication Year 2011
Sub-type Published abstract
DOI 10.1093/alcalc/agr119
ISSN 0735-0414
1464-3502
Volume 46
Issue Suppl. s1
Start page 48
End page 48
Total pages 1
Language eng
Formatted Abstract/Summary
Dopaminergic neurotransmissions play indispensible roles in modulation of
addictive behaviours through personality and stress response. This study aims
at exploring the relationships among personality traits, salivary cortisol and
alcohol craving in alcohol-dependent subjects, and the associations between
these parameters and gene polymorphisms involved. Alcohol-dependent subjects
(n = 156) were recruited during a 5-day detoxification treatment.
Neuroticism (N), extraversion (E) and conscientiousness (C) were measured
by NEO PI-R; harm avoidance (HA), reward dependence (RD), novelty
seeking (NS), persistence (P) and self-directedness (SD) were measured by
Tridimensional Character Inventory. Alcohol craving level was measured by
Alcohol Urge Questionnaire in the morning of day 3–day 5, and a saliva
sample was collected subsequently for cortisol measurement. Genotyping was
done on by PCR-RFLP. Results showed that alcohol craving correlated with
salivary cortisol level in female subjects (Spearman’s ρ = 0.430, P = 0.022)
but not in male subjects. Alcohol craving is significantly (P < 0.05) correlated
with N, C, NS and RD scores for male subjects but with E, C, NS and P
scores for female subjects. Significant correlation between alcohol craving
and these personality traits was only observed in DRD2 TaqIA A1-allele carriers,
whose craving level was negatively correlated with RD scores (adjusted
r2 = 0.191, P < 0.001). Structural equation modeling revealed the effect of
DRD2 TaqIA on alcohol craving is mediated through RD trait. The current
findings suggest that correlations between alcohol craving, salivary cortisol
level and certain addiction-related personality traits are gender-specific.
DRD2 TaqIA polymorphisms may be associated with alcohol craving level
through mediation of RD trait: alcohol-dependent A1-carrying patients with
more prominent RD trait may benefit from a detoxification treatment environment
in which alcohol craving level is low.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes P50

 
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