Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood

Custovic, Adnan, Soderstrom, Lars, Ahlstedt, Staffan, Sly, Peter D., Simpson, Angela and Holt, Patrick G. (2011) Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood. Journal of Allergy and Clinical Immunology, 127 6: 1480-1485. doi:10.1016/j.jaci.2011.03.014

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Author Custovic, Adnan
Soderstrom, Lars
Ahlstedt, Staffan
Sly, Peter D.
Simpson, Angela
Holt, Patrick G.
Title Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2011-06-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.jaci.2011.03.014
Open Access Status Not Open Access
Volume 127
Issue 6
Start page 1480
End page 1485
Total pages 6
Place of publication Milwaukee, WI, United States
Publisher Mosby
Language eng
Formatted abstract
An increase in IgE antibody levels to inhalant allergens is associated with an increased likelihood of wheezing. The role of allergen-specific IgG and IgG4 in relation to wheezing is yet to be determined.


We sought to investigate whether Fel d 1–specific IgG and IgG4 antibodies modify the association between cat allergen–specific IgE and childhood wheezing.


We used data from 2 population-based birth cohorts (United Kingdom [UK], n = 473; Australia, n = 1336). Current wheeze was defined as wheezing in the previous 12 months at age 5 (UK) and 14 (Australia) years. We determined cat allergen–specific IgE (whole extract) and IgG and IgG4 antibody (purified rFel d 1) levels and used logistic regression to estimate the relationship between wheeze and the quantitative allergen antibody levels.


In the univariate analysis risk of wheezing increased significantly with increasing cat-specific IgE levels (UK: odds ratio [OR], 1.56; 95% CI, 1.28-1.90; Australia: OR, 1.29; 95% CI, 1.19-1.40). rFel d 1–specific IgG or IgG4 had no significant effect on wheeze in either population. However, a different pattern of the relationship between antibody levels and wheezing emerged in the multivariate analysis. In the UK cat-specific IgE increased the risk of wheeze (OR, 2.01; 95% CI, 1.29-3.12; P = .002), whereas rFel d 1–specific IgG decreased the risk (OR, 0.46; 95% CI, 0.21-0.99; P = .05). This finding was replicated in Australia (IgE: OR, 1.46; 95% CI, 1.28-1.68; P < .001; IgG: OR, 0.66; 95% CI, 0.44-0.99; P = .049). There was no significant association between IgG4 antibody levels and wheezing in either population.


rFel d 1–specific IgG but not IgG4 antibody levels significantly modify the association between cat-specific IgE and childhood wheezing, with the risk of symptoms decreasing with increasing IgG levels.
Keyword Asthma
Birth cohorts
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 04/014
Institutional Status UQ
Additional Notes Available online 13 April 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
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