Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: A multi-institutional study

Wong, Sandra L., Morton, Donald L., Thompson, John F., Gershenwald, Jeffrey E., Leong, Stanley P. L., Reintgen, Douglas S., Gutman, Haim, Sabel, Michael S., Carlson, Grant W., McMasters, Kelly M., Tyler, Douglas S., Goydos, James S., Eggermont, Alexander M. M., Nieweg, Omgo E., Cosimi, A. Benedict, Riker, Adam I. and Coit, Daniel G. (2006). Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: A multi-institutional study. In: 58th Annual Cancer Symposium of the Society of Surgical Oncology, Atlanta, GA, United States, (809-816). 3-6 March 2005. doi:10.1245/ASO.2006.03.058


Author Wong, Sandra L.
Morton, Donald L.
Thompson, John F.
Gershenwald, Jeffrey E.
Leong, Stanley P. L.
Reintgen, Douglas S.
Gutman, Haim
Sabel, Michael S.
Carlson, Grant W.
McMasters, Kelly M.
Tyler, Douglas S.
Goydos, James S.
Eggermont, Alexander M. M.
Nieweg, Omgo E.
Cosimi, A. Benedict
Riker, Adam I.
Coit, Daniel G.
Title of paper Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: A multi-institutional study
Conference name 58th Annual Cancer Symposium of the Society of Surgical Oncology
Conference location Atlanta, GA, United States
Conference dates 3-6 March 2005
Journal name Annals of Surgical Oncology   Check publisher's open access policy
Place of Publication New York, NY, United States
Publisher Springer
Publication Year 2006
Sub-type Fully published paper
DOI 10.1245/ASO.2006.03.058
Open Access Status Not Open Access
ISSN 1068-9265
1534-4681
Volume 13
Issue 6
Start page 809
End page 816
Total pages 8
Language eng
Formatted Abstract/Summary
Background: Completion lymph node dissection (CLND) is considered the standard of care in melanoma patients found to have sentinel lymph node (SLN) metastasis. However, the therapeutic utility of CLND is not known. The natural history of patients with positive SLNs who do not undergo CLND is undefined. This multi-institutional study was undertaken to characterize patterns of failure and survival rates in these patients and to compare results with those of positive-SLN patients who underwent CLND.
Methods: Surgeons from 16 centers contributed data on 134 positive-SLN patients who did not undergo CLND. SLN biopsy was performed by using each institution's established protocols. Patients were followed up for recurrence and survival.
Results: In this study population, the median age was 59 years, and 62% were male. The median tumor thickness was 2.6 mm, 77% of tumors had invasion to Clark level IV/V, and 33% of lesions were ulcerated. The primary melanoma was located on the extremities, trunk, and head/neck in 45%, 43%, and 12%, respectively. The median follow-up was 20 months. The median time to recurrence was 11 months. Nodal recurrence was a component of the first site of recurrence in 20 patients (15%). Nodal recurrence-free survival was statistically insignificantly worse than that seen in a contemporary cohort of patients who underwent CLND. Disease-specific survival for positive-SLN patients who did not undergo CLND was 80% at 36 months, which was not significantly different from that of patients who underwent CLND.
Conclusions: This study underscores the importance of ongoing prospective randomized trials in determining the therapeutic value of CLND after positive SLN biopsy in melanoma patients.
Keyword melanoma
sentinel lymph node biopsy
completion lymphadenectomy
recurrence
survival
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

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