Augmented Norepinephrine and Renin Output in Response to Maximal Exercise in Hypertensive Coarctectomy Patients

Ross, RD, Clapp, SK, Gunther, S, Paridon, SM, Humes, RA, Farooki, ZQ and Pinsky, WW (1992) Augmented Norepinephrine and Renin Output in Response to Maximal Exercise in Hypertensive Coarctectomy Patients. American Heart Journal, 123 5: 1293-1299. doi:10.1016/0002-8703(92)91036-Z


Author Ross, RD
Clapp, SK
Gunther, S
Paridon, SM
Humes, RA
Farooki, ZQ
Pinsky, WW
Title Augmented Norepinephrine and Renin Output in Response to Maximal Exercise in Hypertensive Coarctectomy Patients
Journal name American Heart Journal   Check publisher's open access policy
ISSN 0002-8703
Publication date 1992-05-01
Year available 1992
Sub-type Article (original research)
DOI 10.1016/0002-8703(92)91036-Z
Open Access Status Not yet assessed
Volume 123
Issue 5
Start page 1293
End page 1299
Total pages 7
Place of publication ST LOUIS
Publisher MOSBY-YEAR BOOK INC
Language eng
Abstract To evaluate a possible neural or renal contribution to the hypertension that occurs in some patients following coarctation of aorta repair, 35 patients underwent graded bicycle exercise with serial measurements of plasma norepinephrine concentrations and plasma renin activity. Sixteen patients with coarctectomy who had systolic or diastolic hypertension at peak exercise were compared with 19 normotensive patients with coarctectomy. The average time interval between coarctation repair and study was significantly longer (p < 0.05) in the hypertensive group than in the normotensive patients (12.8 +/- 4.8 versus 8.7 +/- 2.2 years). The heart rate response to exercise was similar for both patient groups. The systolic blood pressure in the hypertensive group was higher than in the normotensive group at rest in the supine and upright positions and at 5 minutes of recovery, in addition to peak exercise, and the diastolic blood pressure was increased at peak exercise. Plasma norepinephrine concentrations were significantly higher at peak exercise and during recovery in the hypertensive group than in the normotensive patients. Plasma renin activity was also significantly higher in the hypertensive group at peak exercise. These data suggest that patients with coarctectomy who have a hypertensive response to exercise have an augmented sympathetic nervous system output and increased plasma renin activity that may lead to peripheral vasoconstriction at peak exercise and that may contribute to the development of their hypertension.
Keyword Aortic Coarctation
Blood-Pressure
Plasma Norepinephrine
Follow-Up
Children
Repair
Aldosterone
Prediction
Disease
System
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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