Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy

Schildgen, Oliver, Olotu, Cynthia, Funk, Anneke, Zöllner, Bernhard, Helm, Martin, Rockstroh, Jürgen K. and Sirma, Hüseyin (2010) Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy. Journal of Clinical Microbiology, 48 2: 631-634. doi:10.1128/JCM.01073-09

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Author Schildgen, Oliver
Olotu, Cynthia
Funk, Anneke
Zöllner, Bernhard
Helm, Martin
Rockstroh, Jürgen K.
Sirma, Hüseyin
Title Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy
Journal name Journal of Clinical Microbiology   Check publisher's open access policy
ISSN 0095-1137
1098-660X
Publication date 2010-02-01
Sub-type Article (original research)
DOI 10.1128/JCM.01073-09
Open Access Status File (Publisher version)
Volume 48
Issue 2
Start page 631
End page 634
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Recently, we reported on three patients with chronic hepatitis B virus (HBV) infection for whom adefovir (ADF) therapy virologically failed, most likely due to a preexisting rtI233V HBV polymerase mutation. Here, we describe two further patients with chronic HBV infection who were found to develop the rtI233V mutation after initiation of ADF therapy. These patients represent the first cases known so far in which the rtI233V ADF resistance mutation evolved under persistent HBV replication during HBV therapy with ADF. Interestingly, one of the previously described patients, who was initially successfully switched from ADF to tenofovir (TDF) and became virologically suppressed subsequently, experienced a moderate but remarkable rebound of HBV viremia after switching from TDF to entecavir, due to the emergence of renal toxicity. Thus, we provide evidence for the selection and counterselection of the rtI233V ADF resistance mutation during antiviral therapy.
Keyword Hepatitis-B-Virus
Hbv Polymerase
Viral Load
Dipivoxil
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Chemistry and Molecular Biosciences
 
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