Promise and pitfalls of the Immunochip

Cortes, Adrian and Brown, Matthew A. (2011) Promise and pitfalls of the Immunochip. Arthritis Research and Therapy, 13 1: 1-3. doi:10.1186/ar3204

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Author Cortes, Adrian
Brown, Matthew A.
Title Promise and pitfalls of the Immunochip
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1465-9905
1478-6354
1468-3296
Publication date 2011-02-01
Sub-type Editorial
DOI 10.1186/ar3204
Open Access Status File (Publisher version)
Volume 13
Issue 1
Start page 1
End page 3
Total pages 3
Place of publication London, United Kingdom
Publisher BMJ Group
Collection year 2012
Language eng
Abstract Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fi ne-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.
Keyword Missing heritability
Human height
Diseases
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collections: Non HERDC
UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
 
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