Tumor suppressor genes and human cancer

Brown, MA (1997) Tumor suppressor genes and human cancer. Advances in Genetics, Vol 36, 36 C: 45-135. doi:10.1016/S0065-2660(08)60307-7


Author Brown, MA
Title Tumor suppressor genes and human cancer
Journal name Advances in Genetics, Vol 36   Check publisher's open access policy
ISSN 0065-2660
Publication date 1997-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0065-2660(08)60307-7
Open Access Status DOI
Volume 36
Issue C
Start page 45
End page 135
Total pages 91
Language eng
Abstract The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically heterogenous tumors. To evaluate the molecular features of these tumors, 98 ampullary adenocarcinomas were evaluated and compared to 44 distal bile duct and 18 duodenal adenocarcinomas. Genomic analyses revealed mutations in the WNT signaling pathway among half of the patients and in all three adenocarcinomas irrespective of their origin and histological morphology. These tumors were characterized by a high frequency of inactivating mutations of ELF3, a high rate of microsatellite instability, and common focal deletions and amplifications, suggesting common attributes in the molecular pathogenesis are at play in these tumors. The high frequency of WNT pathway activating mutation, coupled with small-molecule inhibitors of β-catenin in clinical trials, suggests future treatment decisions for these patients may be guided by genomic analysis.
Keyword Wild-Type P53
Ataxia-Telangiectasia Gene
Retinoblastoma Susceptibility Gene
Dependent Kinase Inhibitor
Nonpolyposis Colon-Cancer
Cell-Cycle Arrest
Familial Adenomatous Polyposis
Acute Promyelocytic Leukemia
Alternatively Spliced Transcripts
Beckwith-Wiedemann Syndrome
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID P50 CA062924
C596/A18076
U54 HG003273
P30 CA125123
C29717/A17263
HG003273
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: ResearcherID Downloads - Archived
 
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