Amino-Acid Neurotransmitter Receptor Changes in Cerebral-Cortex in Alcoholism - Effect of Cirrhosis of the Liver

Dodd, PR, Thomas, GJ, Harper, CG and Kril, JJ (1992) Amino-Acid Neurotransmitter Receptor Changes in Cerebral-Cortex in Alcoholism - Effect of Cirrhosis of the Liver. Journal of Neurochemistry, 59 4: 1506-1515. doi:10.1111/j.1471-4159.1992.tb08467.x


Author Dodd, PR
Thomas, GJ
Harper, CG
Kril, JJ
Title Amino-Acid Neurotransmitter Receptor Changes in Cerebral-Cortex in Alcoholism - Effect of Cirrhosis of the Liver
Journal name Journal of Neurochemistry   Check publisher's open access policy
ISSN 0022-3042
Publication date 1992-10-01
Year available 1992
Sub-type Article (original research)
DOI 10.1111/j.1471-4159.1992.tb08467.x
Open Access Status Not yet assessed
Volume 59
Issue 4
Start page 1506
End page 1515
Total pages 10
Place of publication PHILADELPHIA
Publisher LIPPINCOTT-RAVEN PUBL
Language eng
Abstract Gamma-aminobutyric acid(A)/benzodiazepine receptor binding sites and the N-methyl-D-aspartate subclass of glutamate receptor sites were assessed in synaptic plasma membrane homogenates of cerebral cortex tissue obtained at autopsy from cirrhotic and noncirrhotic alcoholic patients and matched control subjects. The alcoholic patients consumed an average of >80 g of ethanol/day, the control subjects <20 g/day. Postmortem delays up to approximately 100 h caused no significant loss of any of the binding sites; the patient and subject groups were closely matched for age. The affinities (K(D)) of the receptor sites did not differ between the patient and subject groups, nor between cortical regions. Using three different radioligands ([H-3]muscimol, [H-3]flunitrazepam, and [H-3]diazepam), the gamma-aminobutyric acid(A)/benzodiazepine receptor complex was found to have greater density (B(max)) in superior frontal gyrus in alcoholic patients (which selectively shows morphological change in alcoholic patients), but was unchanged in motor cortex. Alcoholic patients with cirrhosis had much less pronounced changes. The density of the N-methyl-D-aspartate subclass of glutamate receptors, assessed with [H-3]MK-801, did not vary across patient and subject groups.
Keyword Human
Alcoholism
Cirrhosis
Cerebral Cortex
Receptors (amino Acid)
Gamma-Aminobutyric Acid
Benzodiazepine Receptors
Rat-Brain
Hepatic-Encephalopathy
Ionophore Complex
Binding-Sites
Ethanol
Neurons
Synaptoneurosomes
Antagonist
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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