Transcytosis in MDCK cells: identification of glycoproteins transported bidirectionally between both plasma membrane domains.

Brandli, A. W., Parton, R. G. and Simons, K. (1990) Transcytosis in MDCK cells: identification of glycoproteins transported bidirectionally between both plasma membrane domains.. Journal of Cell Biology, 111 6: 2909-2921. doi:10.1083/jcb.111.6.2909

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Author Brandli, A. W.
Parton, R. G.
Simons, K.
Title Transcytosis in MDCK cells: identification of glycoproteins transported bidirectionally between both plasma membrane domains.
Journal name Journal of Cell Biology   Check publisher's open access policy
ISSN 0021-9525
1540-8140
Publication date 1990-12-01
Year available 1990
Sub-type Article (original research)
DOI 10.1083/jcb.111.6.2909
Open Access Status File (Publisher version)
Volume 111
Issue 6
Start page 2909
End page 2921
Total pages 13
Place of publication New York, NY, United States
Publisher Rockefeller University Press
Language eng
Abstract MDCK cells display fluid-phase transcytosis in both directions across the cell. Transcytosis of cell surface molecules was estimated by electron microscopic analysis of streptavidin-gold-labeled frozen sections of biotinylated cells. Within 3 h, approximately 10% of the surface molecules, biotinylated on the starting membrane domain, were detected on the opposite surface domain irrespective of the direction of transcytosis. This suggests that the transcytosis rates for surface molecules are equal in both directions across the cell as shown previously for fluid-phase markers.
Keyword Darby canine kidney
Trans-epithelial transport
Polymeric immunoglobulin receptor
Epidermal growth-factor
Rat hepatocytes
Cellular transport
Mediated transport
Surface polarity
Proteins
Endocytosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 67 times in Thomson Reuters Web of Science Article | Citations
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