Comparison of T Suppressor Factors From Tumor-Bearing Mice and Mice Immunized with a Monoclonal Antiidiotypic Antibody

Greer, JM and Halliday, WJ (1990) Comparison of T Suppressor Factors From Tumor-Bearing Mice and Mice Immunized with a Monoclonal Antiidiotypic Antibody. Cancer Immunology Immunotherapy, 31 3: 151-156. doi:10.1007/BF01744729


Author Greer, JM
Halliday, WJ
Title Comparison of T Suppressor Factors From Tumor-Bearing Mice and Mice Immunized with a Monoclonal Antiidiotypic Antibody
Journal name Cancer Immunology Immunotherapy   Check publisher's open access policy
ISSN 0340-7004
Publication date 1990-05-01
Year available 1990
Sub-type Article (original research)
DOI 10.1007/BF01744729
Open Access Status DOI
Volume 31
Issue 3
Start page 151
End page 156
Total pages 6
Place of publication NEW YORK
Publisher Springer-Verlag
Language eng
Abstract Certain dosage schedules of a monoclonal anti-idiotypic antibody (related to a murine bladder carcinoma) were found to induce suppressor factor production by syngeneic mice. This suppressor factor resembled the factor from tumour-bearing mice with respect to idiotype specificity, possession of molecular markers (reactive with anti-IJ and B16G antibodies) and production by Lyt2+IJ+ T cells in spleen cell cultures. The two factors differed with respect to Igh restriction in an in vitro assay (leucocyte adherence inhibition) and ability to suppress the induction of delayed-type hypersensitivity to tumour antigen.
Keyword Oncology
Immunology
Oncology
Immunology
IMMUNOLOGY
ONCOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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