Effects of Antiidiotype Vaccine On Tumor-Growth and On Production of Soluble Factors Modulating Cell-Mediated-Immunity Invitro

Greer, JM and Halliday, WJ (1991) Effects of Antiidiotype Vaccine On Tumor-Growth and On Production of Soluble Factors Modulating Cell-Mediated-Immunity Invitro. Cancer Immunology Immunotherapy, 33 3: 171-176. doi:10.1007/BF01756138


Author Greer, JM
Halliday, WJ
Title Effects of Antiidiotype Vaccine On Tumor-Growth and On Production of Soluble Factors Modulating Cell-Mediated-Immunity Invitro
Journal name Cancer Immunology Immunotherapy   Check publisher's open access policy
ISSN 0340-7004
Publication date 1991-05-01
Year available 1991
Sub-type Article (original research)
DOI 10.1007/BF01756138
Open Access Status DOI
Volume 33
Issue 3
Start page 171
End page 176
Total pages 6
Place of publication NEW YORK
Publisher Springer-Verlag
Language eng
Abstract The previous observation, that single i.p. doses of a monoclonal anti-idiotypic antibody (MAIA) injected into BALB/c mice induced suppressor factors, was extended to multiple i.v. doses. These induced enhancing factors, which were produced in spleen cell cultures, required L3T4+ cells for their formation, lacked the IJ marker, and bound to anti-immunoglobulin, showing them to be antibodies. Selective immunoabsorption demonstrated two separate enhancing antibodies; both bound to MAIA but they had different affinities for specific and non-specific tumour antigens. Subsequently, single and multiple MAIA doses were tested in vivo for their effects on tumour growth. The single doses had variable effects depending on time of administration, and these effects were tumour-specific; the multiple doses strongly inhibited tumour growth when given before tumour challenge, but also had non-specific effects on another tumour as anticipated from the in vitro results.
Keyword Tumor Immunity
Vaccine
Antiidiotypic Antibody
Bearing Mice
Antibodies
Inhibition
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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