Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats. In: Alcohol and Alcoholism. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, (255-260). Jun 17-22, 1990.

Author Worrall, S
Dejersey, J
Shanley, BC
Wilce, PA
Title of paper Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats
Conference name 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism
Conference location Toronto Canada
Conference dates Jun 17-22, 1990
Proceedings title Alcohol and Alcoholism   Check publisher's open access policy
Journal name Alcohol and Alcoholism   Check publisher's open access policy
Place of Publication OXFORD
Publisher OXFORD UNIV PRESS UNITED KINGDOM
Publication Year 1991
Year available 1991
Sub-type Fully published paper
Open Access Status Not yet assessed
ISSN 0735-0414
Start page 255
End page 260
Total pages 6
Language eng
Abstract/Summary Rats fed ethanol for periods of 3-27 months were found to produce an immune response to acetaldehyde-modified proteins, whereas treatment for a shorter period (3 weeks) did not lead to such a response. The antibodies from the ethanol-fed animals were shown to be reactive with a series of proteins modified by acetaldehyde in vitro. This suggests that reactivity towards the modified proteins is independent of the carrier protein, with antibodies being raised which interact solely with the acetaldehyde-containing adduct and not the protein itself. We have also been able to demonstrate the presence of modified proteins in the liver cytosol of these ethanol-fed rats. However, unlike previous reports which suggested that only one protein was modified, we found that many cytosolic proteins were modified. This suggests that the modification of proteins by acetaldehyde is less specific than was previously thought.
Keyword Rats
Ethanol
Acetaldehyde-Modified Proteins
Immune Response
Antibodies
Alcoholic Liver Disease
Liver-Disease
Adducts
Epitopes
Alcoholism
Albumin
Invivo
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Sub-type: Fully published paper
Collection: ResearcherID Downloads - Archived
 
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