Super-resolution track-density imaging studies of mouse brain: Comparison to histology

Calamante, Fernando, Tournier, Jacques-Donald, Kurniawan, Nyoman D., Yang, Zhengyi, Gyengesi, Erika, Galloway, Graham J., Reutens, David C. and Connelly, Alan (2012) Super-resolution track-density imaging studies of mouse brain: Comparison to histology. NeuroImage, 59 1: 286-296. doi:10.1016/j.neuroimage.2011.07.014

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Author Calamante, Fernando
Tournier, Jacques-Donald
Kurniawan, Nyoman D.
Yang, Zhengyi
Gyengesi, Erika
Galloway, Graham J.
Reutens, David C.
Connelly, Alan
Title Super-resolution track-density imaging studies of mouse brain: Comparison to histology
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2012-01-02
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2011.07.014
Open Access Status File (Author Post-print)
Volume 59
Issue 1
Start page 286
End page 296
Total pages 11
Editor Raja Parasuraman
James Christensen
Scott Grafton
Place of publication Maryland Heights, MO, U.S.A.
Publisher Academic Press
Language eng
Subject 2805 Cognitive Neuroscience
2808 Neurology
Abstract The recently proposed track-density imaging (TDI) technique was introduced as a means to achieve superresolution using diffusion MRI. This technique is able to increase the spatial resolution of the reconstructed images beyond the acquired MRI resolution by incorporating information from whole-brain fibre-tracking results. It not only achieves super-resolution, but also provides very high anatomical contrast with a new MRI contrast mechanism. However, the anatomical information-content of this novel contrast mechanism has not yet been assessed. In this work, we perform such a study using diffusion MRI of ex vivo mouse brains acquired at 16.4T, to compare the results of the super-resolution TDI technique with histological staining (myelin and Nissl stains) in the same brains. Furthermore, a modified version of the directionally-encoded colour TDI map using short-tracks is introduced, which reduces the TDI intensity dynamic range, and therefore enhances the directionality colour-contrast. Good agreement was observed between structures visualised in the superresolution TDI maps and in the histological sections, supporting the anatomical information-content of the images generated using the TDI technique. The results therefore show that the TDI methodology does provide meaningful and rich anatomical contrast, in addition to achieving super-resolution. Furthermore, this study is the first to show the application of TDI to mouse brain imaging: the high-resolution, high-quality images demonstrate the useful complementary information that can be achieved using super-resolution TDI.
Keyword Magnetic resonance imaging
Mouse brain
Diffusion MRI
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online first: 14 July 2011. Special issue: Neuroergonomics: The human brain in action and at work

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 51 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 08 Sep 2011, 00:35:48 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging