Modelling dermal drug distribution after topical application in human

Anissimov, Yuri G. and Roberts, Michael Stephen (2011) Modelling dermal drug distribution after topical application in human. Pharmaceutical Research, 28 9: 2119-2129. doi:10.1007/s11095-011-0437-2


Author Anissimov, Yuri G.
Roberts, Michael Stephen
Title Modelling dermal drug distribution after topical application in human
Journal name Pharmaceutical Research   Check publisher's open access policy
ISSN 0724-8741
1573-904X
Publication date 2011-09-01
Sub-type Article (original research)
DOI 10.1007/s11095-011-0437-2
Volume 28
Issue 9
Start page 2119
End page 2129
Total pages 11
Place of publication Arlington, VA, U.S.A.
Publisher Springer New York
Collection year 2012
Language eng
Formatted abstract
Purpose: To model and interpret drug distribution in the dermis and underlying tissues after topical application which is relevant to the treatment of local conditions.

Methods
: We created a new physiological pharmacokinetic model to describe the effect of blood flow, blood protein binding and dermal binding on the rate and depth of penetration of topical drugs into the underlying skin. We used this model to interpret literature in vivo human biopsy data on dermal drug concentration at various depths in the dermis after topical application of six substances. This interpretation was facilitated by our in vitro human dermal penetration studies in which dermal diffusion coefficient and binding were estimated.

Results: The model shows that dermal diffusion alone cannot explain the in vivo data, and blood and/or lymphatic transport to deep tissues must be present for almost all of the drugs tested.

Conclusion: Topical drug delivery systems for deeper tissue delivery should recognise that blood/lymphatic transport may dominate over dermal diffusion for certain compounds.
Keyword Dermal drug distribution
Modelling
Percutaneous penetration
Topical drug delivery
Percutaneous-absorption kinetics
Hepatic elimination
Dispersion model
Human skin
Clearance
Penetration
Pharmacokinetics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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