The pharmacokinetics and pharmacodynamics of the injectable anaesthetic alfaxalone in the horse

Goodwin, Wendy A., Keates, Helen L., Pasloske, Kirby, Pearson, Martin, Sauer, Ben and Ranasinghe, Millaganamada Gedara (2011) The pharmacokinetics and pharmacodynamics of the injectable anaesthetic alfaxalone in the horse. Veterinary Anaesthesia and Analgesia, 38 5: 431-438. doi:10.1111/j.1467-2995.2011.00634.x


Author Goodwin, Wendy A.
Keates, Helen L.
Pasloske, Kirby
Pearson, Martin
Sauer, Ben
Ranasinghe, Millaganamada Gedara
Title The pharmacokinetics and pharmacodynamics of the injectable anaesthetic alfaxalone in the horse
Journal name Veterinary Anaesthesia and Analgesia   Check publisher's open access policy
ISSN 1467-2987
1467-2995
Publication date 2011-09-01
Sub-type Article (original research)
DOI 10.1111/j.1467-2995.2011.00634.x
Open Access Status Not Open Access
Volume 38
Issue 5
Start page 431
End page 438
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objective: To determine the pharmacokinetics and pharmacodynamics of the neurosteroidal anaesthetic, alfaxalone, in horses after a single intravenous (IV) injection of alfaxalone, following premedication with acepromazine, xylazine and guaiphenesin.

Study design:  Prospective experimental study.

Animals:
Ten (five male and five female), adult, healthy, Standardbred horses.

Methods:
Horses were premedicated with acepromazine (0.03 mg kg−1 IV). Twenty minutes later they received xylazine (1 mg kg−1 IV), then after 5 minutes, guaiphenesin (35 mg kg−1 IV) followed immediately by IV induction of anaesthesia with alfaxalone (1 mg kg−1). Cardiorespiratory variables (pulse rate, respiratory rate, pulse oximetry) and clinical signs of anaesthetic depth were evaluated throughout anaesthesia. Venous blood samples were collected at strategic time points and plasma concentrations of alfaxalone were assayed using liquid chromatography-mass spectrometry (LC/MS) and analysed by noncompartmental pharmacokinetic analysis. The quality of anaesthetic induction and recovery was scored on a scale of 1–5 (1 very poor, 5 excellent).

Results:
The median (range) induction and recovery scores were 4 (3–5) (good: horse slowly and moderately gently attained recumbency with minimal or no rigidity or paddling) and 4 (1–5) (good: horse stood on first attempt with some knuckling and ataxia) respectively. The monitored cardiopulmonary variables were within the range expected for clinical equine anaesthesia. The mean ± SD durations of anaesthesia from induction to sternal recumbency and from induction to standing were 42.7 ± 8.4 and 47 ± 9.6 minutes, respectively. The mean ± SD plasma elimination half life (t1/2), plasma clearance (Clp) and volume of distribution (Vd) for alfaxalone were 33.4 minutes, 37.1 ± 11.1 mL minute−1 kg−1 and 1.6 ± 0.4 L kg−1, respectively.

Conclusions and clinical relevance:
Alfaxalone, in a 2-hydroxypropyl-beta-cyclodextrin formulation, provides anaesthesia with a short duration of recumbency that is characterised by a smooth induction and satisfactory recovery in the horse. As in other species, alfaxalone is rapidly cleared from the plasma in the horse.
Keyword Alfaxalone
Alfaxan
Anaesthetic
Horse
Neurosteroid
Pharmacokinetic
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Veterinary Science Publications
 
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