Accelerated maturation and abnormal morphology in the preterm neonatal kidney

Sutherland, Megan R., Gubhaju, Lina, Moore, Lynette, Kent, Alison L., Dahlstrom, Jane E., Horne, Rosemary S. C., Hoy, Wendy E., Bertram, John F. and Black, M. Jane (2011) Accelerated maturation and abnormal morphology in the preterm neonatal kidney. Journal of the American Society of Nephrology, 22 7: 1365-1374. doi:10.1681/ASN.2010121266

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Author Sutherland, Megan R.
Gubhaju, Lina
Moore, Lynette
Kent, Alison L.
Dahlstrom, Jane E.
Horne, Rosemary S. C.
Hoy, Wendy E.
Bertram, John F.
Black, M. Jane
Title Accelerated maturation and abnormal morphology in the preterm neonatal kidney
Journal name Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1046-6673
1533-3450
Publication date 2011-07-01
Year available 2011
Sub-type Article (original research)
DOI 10.1681/ASN.2010121266
Open Access Status Not yet assessed
Volume 22
Issue 7
Start page 1365
End page 1374
Total pages 10
Place of publication Washington, DC, United States
Publisher American Society of Nephrology
Language eng
Subject 2727 Nephrology
Abstract Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether postnatal renal development follows a similar trajectory to normal in utero growth is unknown. Here, we examined tissue collected at autopsy from 28 kidneys from preterm neonates, whose postnatal survival ranged from 2 to 68 days, including 6 that had restricted intrauterine growth. In addition, we examined kidneys from 32 still-born gestational controls. We assessed the width of the nephrogenic zone, number of glomerular generations, cross-sectional area of the renal corpuscle, and glomerular maturity and morphology. Renal maturation accelerated after preterm birth, with an increased number of glomerular generations and a decreased width of the nephrogenic zone in the kidneys of preterm neonates. Of particular concern, compared with gestational controls, preterm kidneys had a greater percentage of morphologically abnormal glomeruli and a significantly larger cross-sectional area of the renal corpuscle, suggestive of renal hyperfiltration. These observations suggest that the preterm kidney may have fewer functional nephrons, thereby increasing vulnerability to impaired renal function in both the early postnatal period and later in life.
Keyword Low-Birth-Weight
Increased Blood-Pressure
Acute-Renal-Failure
Gestational-Age
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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