NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins

Mattarollo, Stephen R., Yong, Michelle, Gosmann, Christina, Choyce, Allison, Chan, Dora, Leggatt, Graham R. and Frazer, Ian H. (2011) NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins. Journal of Immunology, 187 4: 1601-1608. doi:10.4049/jimmunol.1100756

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Author Mattarollo, Stephen R.
Yong, Michelle
Gosmann, Christina
Choyce, Allison
Chan, Dora
Leggatt, Graham R.
Frazer, Ian H.
Title NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
Publication date 2011-08-01
Sub-type Article (original research)
DOI 10.4049/jimmunol.1100756
Open Access Status File (Author Post-print)
Volume 187
Issue 4
Start page 1601
End page 1608
Total pages 8
Place of publication Bethesda, MD, United States
Publisher American Association of Immunologists
Collection year 2012
Language eng
Formatted abstract
We recently demonstrated that CD1d-restricted NKT cells resident in skin can inhibit CD8 T cell-mediated graft rejection of human papillomavirus E7-expressing skin through an IFN-γ–dependent mechanism. In this study, we examined the role of systemically derived NKT cells in regulating the rejection of skin grafts expressing viral proteins. In lymph nodes draining transplanted skin, Ag-specific CD8 T cell proliferation, cytokine production, and cytotoxic activity were impaired by NKT cells. NKT cell suppression was mediated via CD11c+ dendritic cells. Inhibition of CD8 T cell function did not require Foxp3+ regulatory T cells or NKT cell-secreted IFN-γ, IL-0, or IL-17. Thus, following skin grafting or immunization with human papillomavirus-E7 oncoprotein, NKT cells reduce the capacity of draining lymph node-resident APCs to cross-present Ag to CD8 T cell precursors, as evidenced by impaired expansion and differentiation to Ag-specific CD8 T effector cells. Therefore, in the context of viral Ag challenge in the skin, systemic NKT cells limit the capacity for effective priming of adaptive immunity. 
Keyword Dendritic cells
Tumor immunosurveillance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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