Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides

Nagahama, Koji, Veedu, Rakesh N. and Wengel, Jesper (2009) Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides. Bioorganic and Medicinal Chemistry Letters, 19 10: 2707-2709. doi:10.1016/j.bmcl.2009.03.116

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Author Nagahama, Koji
Veedu, Rakesh N.
Wengel, Jesper
Title Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides
Journal name Bioorganic and Medicinal Chemistry Letters   Check publisher's open access policy
ISSN 0960-894X
Publication date 2009-05-15
Year available 2001
Sub-type Article (original research)
DOI 10.1016/j.bmcl.2009.03.116
Open Access Status File (Author Post-print)
Volume 19
Issue 10
Start page 2707
End page 2709
Total pages 3
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Abstract Synthesis of chimeric 9-mer oligonucleotides containing methylphosphonate-linkages and locked nucleic acid (LNA) monomers, their binding affinity towards complementary DNA and RNA, and their 3′-exonucleolytic stability are described. The obtained methylphosphonate-DNA/LNA chimeric oligonucleotides display similarly high RNA affinity and RNA selectivity as a corresponding 9-mer DNA/LNA chimeric oligonucleotide, but much higher resistance towards 3′-exonucleolytic degradation.
Keyword LNA
RNA targeting
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 GM080784
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Thu, 18 Aug 2011, 22:24:35 EST by Dr Rakesh Naduvile Veedu on behalf of School of Chemistry & Molecular Biosciences