Is weight normalization after childhood liver transplant fat?

Ee, Looi C., Hill, Rebecca J., Beale, Kerrie L., Fawcett, Jonathan and Cleghorn, Geoff (2011). Is weight normalization after childhood liver transplant fat?. In: 2011 DDW Abstract Supplement. Digestive Diseases Week, Chicago, IL, U.S.A., (s941-s941). May 2011. doi:10.1016/S0016-5085(11)63901-2

Author Ee, Looi C.
Hill, Rebecca J.
Beale, Kerrie L.
Fawcett, Jonathan
Cleghorn, Geoff
Title of paper Is weight normalization after childhood liver transplant fat?
Conference name Digestive Diseases Week
Conference location Chicago, IL, U.S.A.
Conference dates May 2011
Proceedings title 2011 DDW Abstract Supplement   Check publisher's open access policy
Journal name Gastroenterology   Check publisher's open access policy
Place of Publication Bethesda, MD, U.S.A.
Publisher W.B. Saunders
Publication Year 2011
Sub-type Published abstract
DOI 10.1016/S0016-5085(11)63901-2
Open Access Status Not Open Access
ISSN 0016-5085
Volume 140
Issue 5, Sp. 1
Start page s941
End page s941
Total pages 1
Language eng
Formatted Abstract/Summary
Introduction: Growth normalization after liver transplant is a desirable long term outcome in children with chronic liver disease. Weight recovery is usually rapid and often normalizes within a year although height recovery can be prolonged. It is unknown whether this recovery occurs as a result of increased body cell mass.

Aims: To assess whether there was improvement in the body cell mass of long term survivors after liver transplant in childhood.

Total body potassium (TBK) measurements to estimate metabolically active body cell mass were performed with a shadow shield whole body counter over a scanning bed. Body cell mass (BCM) was calculated from TBK measurements [BCM (kg) = (TBK*9.18)/39.1], and
adjusted for height and gender (males=BCM/Ht3; females=BCM/Ht2.5). Measurements were performed before and after liver transplant. Paired t-tests were used to analyse the data.

Results: Pre and post transplant measurements were available in 20 patients. There was no difference in the age of transplant or timing of TBK measurement after transplant between the genders. Body cell mass for height was significantly reduced after transplant in long term survivors (t= 3.83, p=0.00). When analysed according to gender, this was significant for boys (t=6.04, p=0.00)but not girls.

Summary/Conclusions: Body cell mass was significantly reduced in long term survivors after liver transplant, especially boys. This implies that fat accumulation is the main reason for weight recovery, which may subsequently predispose
these children to obesity.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: School of Medicine Publications
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Created: Tue, 16 Aug 2011, 22:53:16 EST by Professor Geoffrey Cleghorn on behalf of School of Medicine