The role of immune and inflammatory mechanisms in ALS

McCombe, P. A. and Henderson, R. D. (2011) The role of immune and inflammatory mechanisms in ALS. Current Molecular Medicine, 11 3: 246-254.

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Author McCombe, P. A.
Henderson, R. D.
Title The role of immune and inflammatory mechanisms in ALS
Journal name Current Molecular Medicine   Check publisher's open access policy
ISSN 1566-5240
Publication date 2011-04-01
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 11
Issue 3
Start page 246
End page 254
Total pages 9
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Formatted abstract
Amyotrophic lateral sclerosis (ALS) is a severe progressive neurodegenerative disease. The cause is unknown, but genetic abnormalities have been identified in subjects with familial ALS and also in subjects with sporadic ALS. Environmental factors such as occupational exposure have been shown to be risk factors for the development of ALS. Patients differ in their clinical features and differ in the clinical course of disease. Immune abnormalities have been found in the central nervous system by pathological studies and also in the blood and CSF of subjects with ALS. Inflammation and immune abnormalities are also found in animals with a model of ALS due to mutations in the SOD1 gene. Previously it has been considered that immune abnormalities might contribute to the pathogenesis of disease. However more recently it has become apparent that an immune response can occur as a response to damage to the nervous system and this can be protective.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 55 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 15 Aug 2011, 19:29:49 EST by Matthew Lamb on behalf of School of Medicine