Simultaneous determination of nine UV filters and four preservatives in suncare products by high-performance liquid chromatography

Kim, Kicheol, Mueller, Jochen, Park, Yong-Bae, Jung, Hong-Rae, Kang, Seok-Ho, Yoon, Mi-Hye and Lee, Jeung-Bok (2011) Simultaneous determination of nine UV filters and four preservatives in suncare products by high-performance liquid chromatography. Journal of Chromatographic Science, 49 7: 554-559.

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Author Kim, Kicheol
Mueller, Jochen
Park, Yong-Bae
Jung, Hong-Rae
Kang, Seok-Ho
Yoon, Mi-Hye
Lee, Jeung-Bok
Title Simultaneous determination of nine UV filters and four preservatives in suncare products by high-performance liquid chromatography
Journal name Journal of Chromatographic Science   Check publisher's open access policy
ISSN 0021-9665
1945-239X
Publication date 2011-08-01
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 49
Issue 7
Start page 554
End page 559
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract HPLC method for quantitative determination of four preservatives and nine UV filters worldwide authorized in commercial suncare product was developed and validated, and then 101 samples of commercial suncare products were analyzed for the UV filters and preservatives using the proposed method. The mobile phase was acetonitrile-water containing 0.5% acetic acid using a gradient elution at a flow rate of 0.9 mL/min and UV measurements were carried out at 320 nm for UV filters and 254 nm for preservatives. The correlation coefficients of each calibration curves were mostly higher than 0.999. The percent relative standard deviations (%RSD)ranged from 0.97% to 6.1% for five sample aliquots. The recoveries from the spiked solutions were 98–102%. 2-ethylhexylp-methoxycinnamate (EHMC) was detected in 96 of 101 commercial suncare products and the concentration was in the range of 3.08–8.16% and 18 samples were found to exceed the 7.5% which has been defined as the maximum allowed concentration in Korea. Methyl paraben was detected in 81 of 101 samples and the next-most often detected preservatives were propyl paraben (25), ethyl paraben (18), and butyl paraben (4). Three samples of 101 suncare products exceeded the maximum allowed concentration (i.e., 0.58– 0.79%). The proposed HPLC method allows efficient and simultaneous analysis of preservatives and UV filters suitable for quality control assays of commercial suncare products.
Keyword P-Hydroxybenzoic Acid
Estrogenic Activity
In-Vivo
Cosmetic Products
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
National Research Centre for Environmental Toxicology Publications
 
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Created: Mon, 15 Aug 2011, 19:22:40 EST by System User on behalf of National Res Centre For Environmental Toxicology