16 T Diffusion microimaging of fixed prostate tissue: Preliminary findings

Bourne, Roger, Kurniawan, Nyoman, Cowin, Gary, Syed, Paul and Watson, Geoff (2011) 16 T Diffusion microimaging of fixed prostate tissue: Preliminary findings. Magnetic Resonance in Medicine, 66 1: 244-247. doi:10.1002/mrm.22778

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Author Bourne, Roger
Kurniawan, Nyoman
Cowin, Gary
Syed, Paul
Watson, Geoff
Title 16 T Diffusion microimaging of fixed prostate tissue: Preliminary findings
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 0740-3194
Publication date 2011-07-01
Sub-type Article (original research)
DOI 10.1002/mrm.22778
Open Access Status File (Author Post-print)
Volume 66
Issue 1
Start page 244
End page 247
Total pages 4
Place of publication Hoboken, NJ, United States
Publisher John Wiley and Sons
Language eng
Formatted abstract
Diffusion tensor microimaging was used to investigate the water diffusion properties of formalin-fixed prostate tissue at spatial resolution approaching the cellular scale. Diffusion tensor microimaging was performed at 16.4 T with 40 μm isotropic voxels. Diffusion tensor microimaging clearly demonstrated distinct microscopic diffusion environments and tissue architecture consistent with that seen on light microscopy of the same tissue. The most restricted diffusion environment is the secretory epithelial cell layer (voxel bulk mean diffusivity, D = 0.4 ± 0.1 × 10−3 mm2/sec). Diffusion in the fibromuscular stromal matrix is relatively less restricted (D = 0.7 ± 0.1 × 10−3 mm2/sec). In tumor tissue (Gleason pattern 4+4) distinct glandular and ductal structures are absent in the diffusion-weighted images and diffusivity is low (D = 0.5 ± 0.1 × 10−3 mm2/sec). Distinct stromal and epithelial diffusion compartments are the most likely origin of biexponential diffusion decay observed in vivo.
Keyword Diffusion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
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