MicroRNA regulation of neural plasticity and memory

Bredy, Timothy W., Lin, Quan, Wei, Wei, Baker-Andresen, Danay and Mattick, John S. (2011) MicroRNA regulation of neural plasticity and memory. Neurobiology of Learning and Memory, 96 1: 89-94. doi:10.1016/j.nlm.2011.04.004

Author Bredy, Timothy W.
Lin, Quan
Wei, Wei
Baker-Andresen, Danay
Mattick, John S.
Title MicroRNA regulation of neural plasticity and memory
Journal name Neurobiology of Learning and Memory   Check publisher's open access policy
ISSN 1074-7427
Publication date 2011-07-01
Sub-type Article (original research)
DOI 10.1016/j.nlm.2011.04.004
Volume 96
Issue 1
Start page 89
End page 94
Total pages 6
Place of publication Maryland Heights, MO, U.S.A.
Publisher Academic Press
Collection year 2012
Language eng
Formatted abstract
MicroRNAs (miRNAs) are a class of endogenous, small non-coding RNAs that mediate post-transcriptional gene silencing by complementary binding to the 3′untranslated region of target mRNAs. The transient and localized expression of these small RNAs in dendrites, their capacity to respond in an activity-dependent manner, and the observation that a single miRNA can simultaneously regulate many genes, make brain-specific miRNAs ideal candidates for the fine-tuning of gene expression associated with neural plasticity and memory formation. Here we provide an overview of the current literature, which supports the proposal that non-coding RNA-mediated regulation of gene function represents an important, yet underappreciated, layer of epigenetic control that contributes to learning and memory in the adult brain.

Highlights: ► MicroRNAs are a class of small, non-coding RNAs that regulate gene function by inhibiting translation and/or facilitating degradation of target RNAs. ► A single microRNA can simultaneously regulate many genes. ► MicroRNAs may regulate neural plasticity and memory in three, distinct, but interrelated ways.
Keyword Epigenetic
Noncoding RNAs
Nuclear export
Cocaine intake
Human genome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 57 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 71 times in Scopus Article | Citations
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