Cytokine release from innate immune cells: Association with diverse membrane trafficking pathways

Lacy, Paige and Stow, Jennifer L. (2011) Cytokine release from innate immune cells: Association with diverse membrane trafficking pathways. Blood, 118 1: 9-18. doi:10.1182/blood-2010-08-265892


Author Lacy, Paige
Stow, Jennifer L.
Title Cytokine release from innate immune cells: Association with diverse membrane trafficking pathways
Journal name Blood   Check publisher's open access policy
ISSN 0006-4971
1528-0020
Publication date 2011-07-07
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1182/blood-2010-08-265892
Open Access Status Not yet assessed
Volume 118
Issue 1
Start page 9
End page 18
Total pages 10
Place of publication Washington, DC, United States
Publisher American Society of Hematology
Language eng
Abstract Cytokines released from innate immune cells play key roles in the regulation of the immune response. These intercellular messengers are the source of soluble regulatory signals that initiate and constrain inflammatory responses to pathogens and injury. Although numerous studies describe detailed signaling pathways induced by cytokines and their specific receptors, there is little information on the mechanisms that control the release of cytokines from different cell types. Indeed, the pathways, molecules, and mechanisms of cytokine release remain a “black box” in immunology. Here, we review research findings and new approaches that have begun to generate information on cytokine trafficking and release by innate immune cells in response to inflammatory or infectious stimuli. Surprisingly complex machinery, multiple organelles, and specialized membrane domains exist in these cells to ensure the selective, temporal, and often polarized release of cytokines in innate immunity.
Keyword Hematology
Hematology
HEMATOLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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