Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms

Greer, Judith M. and McCombe, Pamela A. (2011) Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms. Journal of Neuroimmunology, 234 1-2: 7-18. doi:10.1016/j.jneuroim.2011.03.003


Author Greer, Judith M.
McCombe, Pamela A.
Title Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 0165-5728
Publication date 2011-05-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jneuroim.2011.03.003
Open Access Status Not yet assessed
Volume 234
Issue 1-2
Start page 7
End page 18
Total pages 12
Place of publication Amsterdam, AE, Netherlands
Publisher Elsevier BV
Language eng
Subject 2723 Immunology and Allergy
2403 Immunology
2808 Neurology
2728 Clinical Neurology
Abstract Multiple sclerosis (MS) is more prevalent in females than males, and this female predominance is increasing as time goes by. Additionally, gender appears to play critical roles in development, progression and treatment of MS, and is therefore an aspect that should always be considered in the design and interpretation of research and clinical trials for MS. In this review, factors that could potentially explain the gender-biased observations in MS are discussed. These include sex-specific differences between the male and female immune systems and nervous systems, genetic and epigenetic or environmental-related effects, the effects of gonadal hormones, and materno-fetal interactions. (C) 2011 Elsevier B.V. All rights reserved.
Keyword Immunology
Neurosciences
Immunology
Neurosciences & Neurology
IMMUNOLOGY
NEUROSCIENCES
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
School of Medicine Publications
 
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Created: Sat, 13 Aug 2011, 00:13:07 EST by Matthew Lamb on behalf of School of Medicine