High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats

Panchal, Sunil K., Poudyal, Hemant, Iyer, Abishek, Nazer, Reeza, Alam, Ashraful, Diwan, Vishal, Kautner, Kathleen, Sernia, Conrad, Campbell, Fiona, Ward, Leigh, Gobe, Glenda, Fenning, Andrew and Brown, Lindsay (2011) High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. Journal of Cardiovascular Pharmacology, 57 5: 611-624. doi:10.1097/FJC.0b013e3181feb90a

Author Panchal, Sunil K.
Poudyal, Hemant
Iyer, Abishek
Nazer, Reeza
Alam, Ashraful
Diwan, Vishal
Kautner, Kathleen
Sernia, Conrad
Campbell, Fiona
Ward, Leigh
Gobe, Glenda
Fenning, Andrew
Brown, Lindsay
Title High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats
Journal name Journal of Cardiovascular Pharmacology   Check publisher's open access policy
ISSN 0160-2446
Publication date 2011-05-01
Year available 2011
Sub-type Article (original research)
DOI 10.1097/FJC.0b013e3181feb90a
Open Access Status Not yet assessed
Volume 57
Issue 5
Start page 611
End page 624
Total pages 14
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract The prevalence of metabolic syndrome including central obesity, insulin resistance, impaired glucose tolerance, hypertension, and dyslipidemia is increasing. Development of adequate therapy for metabolic syndrome requires an animal model that mimics the human disease state. Therefore, we have characterized the metabolic, cardiovascular, hepatic, renal, and pancreatic changes in male Wistar rats (8-9 weeks old) fed on a high-carbohydrate, high-fat diet including condensed milk (39.5%), beef tallow (20%), and fructose (17.5%) together with 25% fructose in drinking water; control rats were fed a cornstarch diet. During 16 weeks on this diet, rats showed progressive increases in body weight, energy intake, abdominal fat deposition, and abdominal circumference along with impaired glucose tolerance, dyslipidemia, hyperinsulinemia, and increased plasma leptin and malondialdehyde concentrations. Cardiovascular signs included increased systolic blood pressure and endothelial dysfunction together with inflammation, fibrosis, hypertrophy, increased stiffness, and delayed repolarization in the left ventricle of the heart. The liver showed increased wet weight, fat deposition, inflammation, and fibrosis with increased plasma activity of liver enzymes. The kidneys showed inflammation and fibrosis, whereas the pancreas showed increased islet size. In comparison with other models of diabetes and obesity, this diet-induced model more closely mimics the changes observed in human metabolic syndrome.
Keyword Metabolic syndrome
Cardiovascular disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 05 Aug 2011, 22:03:13 EST by Susan Allen on behalf of Institute for Molecular Bioscience