Refining the estimation of illicit drug consumptions from wastewater analysis: Co-analysis of prescription pharmaceuticals and uncertainty assessment

Lai, Foon Yin, Ort , Christoph, Gartner, Coral, Carter, Steve, Prichard, Jeremy, Kirkbride, Paul, Bruno, Raimondo, Hall, Wayne, Eaglesham, Geoff and Mueller, Jochen F. (2011) Refining the estimation of illicit drug consumptions from wastewater analysis: Co-analysis of prescription pharmaceuticals and uncertainty assessment. Water Research, 45 15: 4437-4448. doi:10.1016/j.watres.2011.05.042


Author Lai, Foon Yin
Ort , Christoph
Gartner, Coral
Carter, Steve
Prichard, Jeremy
Kirkbride, Paul
Bruno, Raimondo
Hall, Wayne
Eaglesham, Geoff
Mueller, Jochen F.
Title Refining the estimation of illicit drug consumptions from wastewater analysis: Co-analysis of prescription pharmaceuticals and uncertainty assessment
Journal name Water Research   Check publisher's open access policy
ISSN 0043-1354
1879-2448
Publication date 2011-10-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.watres.2011.05.042
Open Access Status Not Open Access
Volume 45
Issue 15
Start page 4437
End page 4448
Total pages 12
Place of publication Lisle, IL, United States
Publisher I W A Publishing
Language eng
Subject 2312 Water Science and Technology
2311 Waste Management and Disposal
2310 Pollution
2302 Ecological Modelling
Abstract Wastewater analysis is a promising monitoring tool to estimate illicit drug consumption at the community level. The advantage of this technique over traditional surveys and other surveillance methods has been emphasized in recent studies. However, there are methodological challenges that can affect reliability. The objectives of this study were to systematically reduce and assess uncertainties associated with sampling (through a stringent optimization of the sampling method) and the back calculation of per capita drug consumption (through a refined estimation of the number of people actively contributing to the wastewater in a given period). We applied continuous flow-proportional sampling to ensure the collection of representative raw wastewater samples. Residues of illicit drugs, opioids, prescription pharmaceuticals and one artificial sweetener were analyzed by liquid chromatography coupled with tandem mass spectrometry. A parameter estimating the number of people actively contributing to wastewater over a given period was calculated from the measured loads of prescription pharmaceuticals, their annual consumption and relative excretion data. For the calculation of substance loads in sewage, uncertainties were propagated considering five individual components: sampling, chemical analysis, flow measurements, excretion rates and the number of people contributing to the wastewater. The daily consumption per 1000 inhabitants was estimated to be almost 1000 mg for cannabis and several hundred mg for cocaine, methamphetamine and ecstasy. With the best sampling practice and current chemical analysis, we calculated the remaining uncertainty to be in the range of 20e30% (relative standard deviation, RSD) for the estimation of consumed drug masses in the catchment; RSDs for the per capita consumption were lower (14e24%), as one of the biggest uncertainty components (i.e. error in flow measurements) cancels out in the proposed method for the estimation of the number of people contributing to the daily wastewater volume. In this study, we provide methodological improvements that substantially enhance the reliability of the estimation method e a prerequisite for the application of this technique to meaningfully assess changes in drug consumption and the success of drug intervention strategies in future studies.
Keyword Normalization
Estimated population
Error propagation
LC-MS/MS
Australia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 26 Jul 2011, 08:03:31 EST by Hong Lee on behalf of Advanced Water Management Centre